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IRCT20120817010617N8 IRCT 2021-07-21 Zahedan University of Medical Sciences Evaluation of IVF Outcomes in Patients with Decreased Ovarian reserve with Double Stimulation Compared with conventional Antagonist Cycle Evaluation of IVF Outcomes in Patients with Decreased Ovarian reserve with Double Stimulation during Follicular and Luteal Phase Compared with conventional Antagonist Cycle 2021-07-11 anticipated 54 Complete https://irct.ir/trial/56806 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random assignment of patients to two groups will be done by permutation block stratified randomization method. Eligible patients will be classified according to age and BMI, respectively. Then, based on 4 blocks (consisting of two groups A and B and two repetitions for each) patients will be randomly selected from all possible modes of permutations, and will be assigned to the desired group, Blinding description: In this clinical trial, the Single-Blinding method will be used. So that the technician responsible for recording of the consequences will not be aware of the intervention. 2-3 Infertility. Intervention 1: Intervention group: Double Stimulation, Patient's receipt HMG and FSH from day 2 and then when the follicle is upper 13-millimeter cetrotide is consumed and when the follicle is upper 18 mliletr HCG is injected and after 36 hours puncture of the follicles is done. From the day after the puncture, patients receive one steroid antagonist daily for 4 days to lower hormone levels. Intervention 2: Intervention group: conventional Antagonist Cycle, Patients reciept cetrotide for three days that started from day 2 and after that HMG and FSH is started and then when the follicle is upper 13-millimeter cetrotide is consumed and when the follicle is upper 18 mliletr HCG is injected and after 36 hours puncture of the follicles is done. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is not decided
public Fateme Qahqaei
Ali-ebn Abi Talib Hospital, Salamat Blvd, Dr.Hesabi Sq.
Zahedan Iran (Islamic Republic of) 9816743111 +98 54 3329 5570 morimedico@yahoo.com Zahedan University of Medical Sciences scientific Fateme Qahqaei
Ali-ebn Abi Talib Hospital, Salamat Blvd, Dr.Hesabi Sq.
Zahedan Iran (Islamic Republic of) 9816743111 +98 54 3329 5570 morimedico@yahoo.com Zahedan University of Medical Sciences Iran (Islamic Republic of) Patients with reduced ovarian reserve who are candidates for IVF. Endometriosis less than grade 3. No contraindications to use of ovarian stimulation medications. At the same time, the patient's partner should not have azoospermia. no limit 40 years Female N97 Female infertility Treatment - Drugs Treatment - Drugs Intervention group: Double Stimulation, Patient's receipt HMG and FSH from day 2 and then when the follicle is upper 13-millimeter cetrotide is consumed and when the follicle is upper 18 mliletr HCG is injected and after 36 hours puncture of the follicles is done. From the day after the puncture, patients receive one steroid antagonist daily for 4 days to lower hormone levels. Intervention group: conventional Antagonist Cycle, Patients reciept cetrotide for three days that started from day 2 and after that HMG and FSH is started and then when the follicle is upper 13-millimeter cetrotide is consumed and when the follicle is upper 18 mliletr HCG is injected and after 36 hours puncture of the follicles is done. Total oocyte recovery rate. Timepoint: After oocyte retrieval. Method of measurement: Via Ultrasound Sonography. The mean Metaphase II (MII) oocyte counts. Timepoint: Oocyte pick up day. Method of measurement: Microscopic assay. The number of fetus. Timepoint: After puncture. Method of measurement: Microscopic assay -The number of fetuses after injection. Zahedan University of Medical Sciences Approved 2021-01-10 Ethics Committee of Zahedan University of Medical Sciences Dr.Hesabi Square Zahedan Sistan-va-Balouchestan Iran (Islamic Republic of)