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IRCT20200302046669N1 IRCT 2021-06-12 Ahvaz University of Medical Sciences بررسی اثر بخشی میکرونیدلینگ با ترانگزامیک اسید در مقایسه با میکرونیدلینگ و ویتامین سی در درمان تیرگی دور چشم بررسی اثر بخشی میکرونیدلینگ با ترانگزامیک اسید در مقایسه با میکرونیدلینگ و ویتامین سی در درمان تیرگی دور چشم 2021-06-10 anticipated 37 Complete https://irct.ir/trial/56802 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Our two comparison groups are both under the eyes, and we have two treatment groups, A and B.For randomization, in treatment method A, microneedling and tranexamic treatment is considered for the right side of the patient's face and microneedling and vascorbic acid treatment is considered for the left side. In treatment method B, it will be the opposite.This means that we will dedicate the right side of the patient's face to the treatment of vascorbic acid microneedling and the left side to the microneedling and tranexamic treatment. Using the coin toss method, method A will be assigned to the patient if observed, and treatment method B will be assigned to the patient if the line is observed, Blinding description: The study is one-sided blind in which only the participant is kept blind. The participant is aware of the type of drugs used but is not aware of how they are allocated to the left or right Under the eyes. 3 infraorbital dark circle. Intervention 1: Intervention group: Microneedling to a depth of 2 to 3 mm of the skin with tranexamic acid 3 times at intervals of 2 weeks on one side under the eye. Random selection. Intervention 2: Intervention group: Microneedling to a depth of 2 to 3 mm with vitamin C skin 3 times 2 weeks apart on one side under the eye. Random selection. Yes - There is a plan to make this available What will be shared: Personal information of participants including age, sex, complications and degree of hyperpigmentation under the eyes before and after microneedling along with tranexamic acid and microneedling with vitamin C When: Access period starts 6 months after the results are published To whom: Researchers working in academic and scientific institutions Conditions: Dermatologists Academic researchers Permitted analyzes: descriptive Where to obtain: badakhsh_f@yahoo.com tel : 00989127087284 How to obtain: The requested information will be provided to the applicant one month after receiving the email. Comments:
public Fatemeh Badakhsh
No. 5, 19th Street, Kianpars
Ahvaz Iran (Islamic Republic of) 6155887137 +98 61 3337 4866 badakhsh_f@yahoo.com Ahvaz University of Medical Sciences scientific Fatemeh Badakhsh
No. 5, 19th Street, Kianpars
Ahvaz Iran (Islamic Republic of) 6155887137 +98 61 3337 4866 badakhsh_f@yahoo.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) People 18 to 50 years old with dark circles around the eyes 18 years 50 years Both Pregnant women and breastfeeding mothers Taking oral contraceptive pills during the last 12 months and during the study Existence of any history of coagulation disorders and thrombotic problemsCommunity Verified icon Taking anticoagulants Existence of allergy to the studied drugs and topical lidocaine History of dark circles treatment around the eyes during the last six months Hereditary or acquired connective tissue diseases History of colloidal scarring History of isotretinoin use within one year before treatment H02.71 Chloasma of eyelid and periocular area Treatment - Other Treatment - Other Intervention group: Microneedling to a depth of 2 to 3 mm of the skin with tranexamic acid 3 times at intervals of 2 weeks on one side under the eye. Random selection Intervention group: Microneedling to a depth of 2 to 3 mm with vitamin C skin 3 times 2 weeks apart on one side under the eye. Random selection Percentage of improvement of opacity after 3 sessions of treatment. Timepoint: It is done at the beginning of the study and weeks 2, 4, 8 and 12. Method of measurement: عکس برداری با دوربین. Vice Chancellor for Research, Ahvaz University of Medical Sciences Approved 2021-06-09 Ethics Committee of Ahvaz Jundishapur University of Medical Sciences 13th floor, Block A ,Treatment and Medical Education ,Headquarters of the Ministry of Health, Iran TV St ,between South Flamek and Zarafshan ,Ghods Town (West), Tehran ahvaz Khouzestan Iran (Islamic Republic of)