IRCT20200217046523N17 IRCT 2021-06-19 Artesh University of Medical Sciences Nigella sativa extract and depression Evaluation of therapeutic effects of Nigella sativa extract on serum Brain-Derived Neurotrophic Factor (BDNF) and depression and anxiety score in patients with depression 2021-08-09 anticipated 50 Complete https://irct.ir/trial/56618 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Depression. Intervention 1: Intervention group: Patients in this group will be evaluated for depression severity through Depression, Anxiety and Stress Scale - 21 (DASS-21) questionnaire and serum BDNF through ELISA kits after entering the study. Patients will be then treated with capsules containing 1000 mg of Nigella sativa extract daily along with sertraline. After 6 weeks, the patients' depression level as well as the level of serum BDNF in them will be measured again. Intervention 2: Control group: Patients in this group will be evaluated for depression severity through Depression, Anxiety and Stress Scale - 21 (DASS-21) questionnaire and serum BDNF through ELISA kits after entering the study. Patients will be then receiving placebo capsules, daily, containing starch along with sertraline. After 6 weeks, the patients' depression level as well as the level of serum BDNF in them will be measured again. Yes - There is a plan to make this available What will be shared: All data can be shared after people have requested. When: Six months after publishing the results. To whom: Academic researchers Conditions: Scientific uses Where to obtain: Website of the Research Committee of Artesh University of Medical Sciences How to obtain: Clear request on the site to access the data by the individual and then review the request by the research assistant within 2 weeks and then allow access to the data. Comments: