IRCT201205265283N4 IRCT 2013-03-16 Women's Reproductive Health Research Center, Tabriz University of Medical Sciences Comparing the effect of Metformin and Megestrol acetate on endometrial histology in patients with disordered proliferative or hyperplastic endometrium. A RCT Comparing the effect of Metformin and Megestrol acetate on endometrial histology in patients with disordered proliferative or hyperplastic endometrium. A RCT 2011-12-22 anticipated 90 Complete https://irct.ir/trial/5655 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 2 Patients with abnormal uterine bleeding and have disordered proliferative or hyperplastic endometrium with or without atypia. Intervention 1: First group: fifteen cases with disordered proliferative endometrium , 15 cases with hyperplastic atypical endometrium and 15 cases with hyperplasticendometrium and without atypia who referred to Alzahra Teaching Hospital, are included and after getting written informed consent, metformin is given for 3 months, then endometrial biopsy will be carried out and the response to therapy will be compared according to the pathologic results. Intervention 2: Second group: fifteen cases with disordered proliferative endometrium , 15 cases with hyperplastic atypical endometrium and 15 cases with hyperplastic endometrium and without atypia who referred to Alzahra Teaching Hospital, are included and after getting written informed consent, megestrol acetate is given for 3 months, then endometrial biopsy will be carried out and the response to therapy will be compared according to the pathologic results.