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IRCT20100127003210N22 IRCT 2021-07-05 Shahid Beheshti University of Medical Sciences Cyproheptadine in Schizophrenia Evaluation the effect of Cyproheptadine on relieving the negative and positive symptoms of patients with schizophrenia or schizoaffective 2021-07-23 anticipated 30 Complete https://irct.ir/trial/56237 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple Individual Randomization with the Card in Two Groups A and B, in this Way a Number of Cards are selected as the first Intervention Group and the same Number in the control Group, then by merging the Cards together one Card is drawn and its Allocation is recorded and the Card is returned to the other Cards after it has been removed. The Cards are then re-merged and another Card is withdrawn. The Process continues until a Random Sequence Sample Size is reached. 3 Schizophrenia. Intervention 1: Intervention group: receiving Cyproheptadine by dose of 8 mg per day in form of two 4mg tablet twice a day in addition to receiving risperidone 4-6 mg daily as an antipsychotic. Intervention 2: Control group: receiving risperidone 4-6 mg daily as an antipsychotic. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is not more data.
public Farnaz Kongi
Shahid Beheshti School of Pharmacy, Hashemi Rafsanjani Highway ,Valiasr St.
Tehran Iran (Islamic Republic of) 1996835113 +98 21 8820 0118 fariano.ko@gmail.com Shahid Beheshti University of Medical Sciences scientific Maria Tavakoli Ardakani
Shahid Beheshti School of Pharmacy, Hashemi Rafsanjani Highway , Valiasr St.
Tehran Iran (Islamic Republic of) 1996835113 +98 21 8820 0118 mariatavakoli@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Ages 18-65 years Diagnosis of schizophrenia or schizoaffective disorder (Deppresive type) based on DSM-V Taking Risperidone as an Antipsychotic Fill in the consent 18 years 65 years Both Antipsychotic treatment other than Risperidone History of non-response to second generation antipsychotic treatment Drug abuse Thyroid Disorder Pregnancy and Lactation F20 Schizophrenia Treatment - Drugs Treatment - Drugs Intervention group: receiving Cyproheptadine by dose of 8 mg per day in form of two 4mg tablet twice a day in addition to receiving risperidone 4-6 mg daily as an antipsychotic. Control group: receiving risperidone 4-6 mg daily as an antipsychotic Positive and Negative Syndrome. Timepoint: At the beginning of the study, the first week, the second week, the fourth week, the sixth week. Method of measurement: PANSS Questionnaire. Shahid Beheshti University of Medical Sciences Approved 2020-06-01 Ethics committee of Shahid Beheshti University of Medical Sciences Niayesh Highway, Valiasr Ave, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)