IRCT20210415050976N1 IRCT 2021-05-17 Jahrom University of Medical Sciences Comparison of the effect of coma induced by thiopental and propofol in Traumatic Brain Injury patients Comparison of the effect of coma induced by thiopental and propofol in Traumatic Brain Injury patients admitted in intensive care unit 2021-05-31 anticipated 60 Complete https://irct.ir/trial/56190 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients participating in the present study will be divided into two groups: propofol and sodium thiopental by tossing coins, Blinding description: For blinding, in the present study, the double-blind method is used so that the person reviewing the results and the person performing the injections do not know which patients received propofol and which thiopental sodium. The syringes will be covered with black glue. 2-3 Patients with traumatic brain injury. Intervention 1: Intervention group 1: Patients in group 1 will receive sodium thiopental drug in the intensive care unit as a bolus of 2 mg per kg of body weight and a maintenance dose of 2 to 6 mg per kg of body weight per hour. Intervention 2: Intervention group 2: Patients in group two will receive propofol in the intensive care unit as a bolus of 5 mg per kg of body weight and a maintenance dose of 3 to 4.5 mg / kg of body weight per hour. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.