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IRCT20151228025732N67 IRCT 2021-05-24 Semnan University of Medical Sciences Comparison of the effect of single preoperative dose of Gabapentin and Pregabalin on postoperative pain after laparoscopic cholecystectomy in patients Comparison of the effect of single preoperative dose of Gabapentin and Pregabalin on postoperative pain after laparoscopic cholecystectomy in patients 2021-06-05 anticipated 75 Complete https://irct.ir/trial/56187 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are allocated randomly with simple sequential allocation in one of the three study groups by help of sealed envelope and receive the intervention of the same group. The unit of randomization is patient. Sealed envelopes are delivered to expert. With each patient's visit, one of the envelopes is randomly selected by the patients and determines the study group. The stratification approach is not used. 3 Pain. Intervention 1: Intervention group 2: One hour before the operation, the patient is given 600 mg of gabapentin capsules with some water. Paracetamol ampules are used to relieve postoperative pain in patients. Intervention 2: Intervention group 2: One hour before the operation, the patient is given 150 mg of pregabalin capsule with some water. Paracetamol ampules are used to relieve postoperative pain in patients. Intervention 3: Control group: One hour before the operation, the patient is given a placebo (domperidone 10 mg capsule) with a little water. Paracetamol ampules are used to relieve postoperative pain in patients. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.
public Setareh Soltany
Semnan University of Medical Sciences, Basij Blvd, Semnan.
Semnan Iran (Islamic Republic of) 3514799442 +98 23 3345 1336 are20935@gmail.com Semnan University of Medical Sciences scientific Setareh Soltany
Semnan University of Medical Sciences, Basij Blvd, Semnan.
Semnan Iran (Islamic Republic of) 3514799442 +98 23 3345 1336 are20935@gmail.com Semnan University of Medical Sciences Iran (Islamic Republic of) Age 25 to 60 years Candidates for elective laparoscopic cholecystectomy 25 years 60 years Both Drug addiction Liver or kidney disorders Taking anticonvulsants or antidepressants Breastfeeding G89.1 Acute pain, not elsewhere classified Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 2: One hour before the operation, the patient is given 600 mg of gabapentin capsules with some water. Paracetamol ampules are used to relieve postoperative pain in patients. Intervention group 2: One hour before the operation, the patient is given 150 mg of pregabalin capsule with some water. Paracetamol ampules are used to relieve postoperative pain in patients. Control group: One hour before the operation, the patient is given a placebo (domperidone 10 mg capsule) with a little water. Paracetamol ampules are used to relieve postoperative pain in patients. Pain. Timepoint: At 1, 2, 6, 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale (VAS). Frequent demand for narcotic housing. Timepoint: Number of times the patient requests after the operation. Method of measurement: Questionnaire. Duration of surgery. Timepoint: From the beginning of the surgery to its end. Method of measurement: Questionnaire. Semnan University of Medical Sciences Approved 2021-04-27 Ethics committee of Semnan University of Medical Sciences Semnan University of Medical Sciences, Basij Blvd, Semnan Semnan Semnan Iran (Islamic Republic of)