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IRCT20210427051100N1 IRCT 2021-06-19 Tehran University of Medical Sciences selenium in covid_19 The effect of selenium supplementation on inflammatory markers and blood cells in patients with Covid 19 double-blind randomized clinical trial 2021-06-30 anticipated 40 Complete https://irct.ir/trial/55898 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Due to the fact that the sample size of these studies is 40 people, to maintain the balance between the two groups, the block randomization method will be used so that 10 four-person blocks including 2 people in the intervention group and 2 others in the placebo group will be formed and distinguished. The placement of individuals in each block will be using a table of random numbers so that in the table of random numbers from top to bottom even numbers will be assigned to the intervention group and odd numbers to the placebo group, Blinding description: The subjects will be assigned to two groups receiving selenium supplementation and placebo group. The subjects in the intervention group, in addition to their usual treatments, will take 1 capsule of 200 micrograms daily for 2 weeks, and the placebo group will have 1 capsule of placebo daily, which is completely similar in appearance, color, smell and shape to selenium capsules. . The placebo capsule will contain maltodextrin. Supplements and placebos will be provided to patients by a third party who is not directly involved in the research process. Therefore, all patients and researchers will be unaware of the existing grouping. To assess patient admission, a checklist will be prepared and provided to the patient and they will be asked to record their daily intake. 3 Covid-19. Intervention 1: Intervention group: Intervention group: includes 20 patients with COVID-19 who, in addition to their usual treatments, will take 1 capsule of 200 micrograms of selenium daily for 2 weeks (14 days) after meals. Intervention 2: Intervention group: Control group: includes 20 patients with COVID-19 who, in addition to their usual treatments, will take 1 placebo tablet (maltodextrin) daily for 2 weeks (14 days) after meals. Placebo capsules are very similar in appearance, color, smell and shape to selenium capsules. Yes - There is a plan to make this available What will be shared: All information can be shared two months after the results are published When: Two months after the publication of the results To whom: Physicians, nurses, and infectious disease specialists Conditions: To evaluate other complementary therapies and compare its effect with existing treatment related to COVID-19 disease Where to obtain: Send an email to mortezakhamoushi@gmail.com How to obtain: Two months after the results are published, send a written request to mortezakhamoushi@gmail.com. In this case, and finally within one month after receiving the email, the request will be answered. Comments:
public Amirhossein hemati
Faculty of Nutrition and Dietetics, University of Medical Sciences and Health Services, Tehran, Keshavarz Blvd., Naderi St., Hojjatdoost Alley, No. 44
Tehran Iran (Islamic Republic of) 3439123900 +98 21 8895 5975 amirhemati2000@gmail.com Tehran University of Medical Sciences scientific Dr. Hossein Imani
Faculty of Nutrition and Dietetics, University of Medical Sciences and Health Services, Tehran, Keshavarz Blvd., Naderi St., Hojjatdoost Alley, No. 44
Tehran Iran (Islamic Republic of) 3439123900 +98 21 8895 5975 h-imani@sina.tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Detection of COVID-19 based on PCR tests Being 20 to 60 years old Willingness to participate in the study 20 years 60 years Both Breastfeeding and pregnancy Advanced respiratory distress syndrome leading to intubation U07.1 COVI U07.1 COVICOVID-19 , virus identified Treatment - Drugs Placebo Intervention group: Intervention group: includes 20 patients with COVID-19 who, in addition to their usual treatments, will take 1 capsule of 200 micrograms of selenium daily for 2 weeks (14 days) after meals. Intervention group: Control group: includes 20 patients with COVID-19 who, in addition to their usual treatments, will take 1 placebo tablet (maltodextrin) daily for 2 weeks (14 days) after meals. Placebo capsules are very similar in appearance, color, smell and shape to selenium capsules. Serum levels of reactive protein-C. Timepoint: The first day and the last day of the intervention. Method of measurement: Blood test. Serum levels of interleukin-6. Timepoint: The first day and the last day of the intervention. Method of measurement: Using blood sampling, the amount of serum IL6 in pc / dl by the kit. Blood leukocyte count. Timepoint: The first day and the last day of the intervention. Method of measurement: blood test. Complete number of lymphocytes. Timepoint: The first day and the last day of the intervention. Method of measurement: blood test. Complete number of neutrophils. Timepoint: The first day and the last day of the intervention. Method of measurement: blood test. Lactate Dehydrogenase. Timepoint: The first day and the last day of the intervention. Method of measurement: blood test. Ferritin. Timepoint: The first day and the last day of the intervention. Method of measurement: blood test. Tehran University of Medical Sciences Approved 2021-04-17 Ethics Committee in Medical School Research - Tehran University of Medical Sciences Central Headquarters of Tehran University of Medical Sciences, Corner of Ghods, Keshavarz Blvd Tehran Tehran Iran (Islamic Republic of)