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IRCT20210302050553N1 IRCT 2021-05-14 Zanjan University of Medical Sciences Comparison of analgesic effect of rupivacaine with dexamethasone and rupivacaine with dexmedetomidine Comparison of Ropivacaine combination with Dexamethasone analgesic effect and Ropivacaine combination with dexmedetomidine on pain after cesarean section by TAP Block method 2021-05-22 anticipated 100 Complete https://irct.ir/trial/55777 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The method of randomization of patients will be random block. Based on the calculated sample size, the sample size in each group is 25 patients. positions are considered as 6 positions according to 2 groups: AABB, ABAB, BBAA, BABA, BAAB, ABBA. The positions are written on 6 cards and the selection of positions and their order will be randomly selected among the cards. The order of exit of the cards is written and will determine the order of recruitment of intervention groups based on it. Individuals will be assigned on a per-shift basis. An individual randomization unit will be used for the study. The information of registered persons will be anonymous and without their personal information, Blinding description: Pregnant women participating in the study will be unaware of the type of drug used to perform the TAP block and will not be given any information about the drug used at the time of injection, and only the researcher and injector will be informed of the type of drug. 3 Post procedural pain. Intervention 1: Intervention group: Bilateral block method by transverse abdominis plane, 15 cc of 2% ropivacaine, and 100 micrograms of dexmedetomidine will be injected between the transverse abdominis and rectus abdominis muscles. Intervention 2: Intervention group: Bilateral block method by transverse abdominis plane, 15 cc of 2% ropivacaine 2% with 2 cc of dexamethasone will be injected between the transverse abdominis and rectus abdominis muscles. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The decision will be made after the results are known.
public Mohammad Reza Jamshidi
Gavazang
Zanjan Iran (Islamic Republic of) 4513956183 +98 24 3313 0000 mr.jamshidi47@gmail.com Zanjan University of Medical Sciences scientific Mohammad Reza Jamshidi
Gavazang
Zanjan Iran (Islamic Republic of) 4513956183 +98 24 3313 0000 mr.jamshidi47@gmail.com Zanjan University of Medical Sciences Iran (Islamic Republic of) ASA(American Society of Anesthesiologists) grade 1 or 2 The patient's ability to report the extent of their pain by criteria VAS(visual analog scale) Conscious consent of the patient to participate in the study Candidate for cesarean section under anesthesia with TAP(transverse abdominis plane) block 18 years no limit Both History of anaphylaxis to dexmedetomidine or ropivacaine History of drug abuse History of coagulopathy G89.18 Other acute postprocedural pain Treatment - Drugs Treatment - Drugs Intervention group: Bilateral block method by transverse abdominis plane, 15 cc of 2% ropivacaine, and 100 micrograms of dexmedetomidine will be injected between the transverse abdominis and rectus abdominis muscles. Intervention group: Bilateral block method by transverse abdominis plane, 15 cc of 2% ropivacaine 2% with 2 cc of dexamethasone will be injected between the transverse abdominis and rectus abdominis muscles. Pain of patients after cesarean section. Timepoint: 24 hours after surgery. Method of measurement: By visual analog scale questionnaire. Zanjan University of Medical Sciences Approved 2021-04-11 Ethics committee of Zanjan University of Medical Science Gavazang Zanjan Zanjan Iran (Islamic Republic of)