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IRCT20210412050945N1 IRCT 2021-05-02 Karaj University of Medical Sciences Comparison of the effects of medroxyprogestron and megestrol on vasomotor symptom in menopause women Comparison of the effects of medroxyprogestron 10 mg and megestrol 40 mg on vasomotor symptom in menopause women 2021-05-10 anticipated 80 Complete https://irct.ir/trial/55739 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Women who consented to participate are randomly selected to receive either medroxyprogestron or megestrol . Group assignment is determined from a computer-generated table of random numbers. Some opaque envelopes were used for concealment, Blinding description: Completion of the final information is up to the person who is unaware of the type of treatment and also the specialist will be blind. Patients are unaware of the type of treatment. 3 Menopausal hot flashes. Intervention 1: Intervention group: Magestrol tablets 40 mg daily for 1 month. Intervention 2: Intervention group: Medroxyprogesterone 10 mg daily for one month. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It is not yet known if there will be a plan to make this available
public Samira Abdollahi
Kamali hospital; Shahid behesh ave.;shohada square;Karaj
Alborz Iran (Islamic Republic of) 3149779453 +98 26 3222 2021 S.abdolahi@abzums.ac.ir Karaj University of Medical Sciences scientific Samira Abdollahi
Kamali hospital; Shahid behesh ave.;shohada square;Karaj
Alborz Iran (Islamic Republic of) 3149779453 +98 26 3222 2021 S.abdolahi@abzums.ac.ir Karaj University of Medical Sciences Iran (Islamic Republic of) Iranian women 40-60 years old Married With a history of childbirth; She had the last period 12 month later and serum FSH level is more than 40 million units per ml; Lack of known physical or mental illness; Experience at least 3 hot flashes during the day No addiction or smoking, hookah or alcohol Body mass index less than or equal to 29 Minimum literacy Women with and had at least one of the symptoms of menopausal vasomotor Natural menopause and menopause due to ovarian removal No known mental illness 40 years 60 years Female Regular exercise program Vegetarian diet Consume soy and its products more than once a week Current use of drugs that affect hot flashes. Symptoms of drug allergy Failure to record the number of hot flashes in the relevant checklists Taking any medicine during research The presence of severe stress during treatment N95 Menopausal and other perimenopausal disorders Treatment - Drugs Treatment - Drugs Intervention group: Magestrol tablets 40 mg daily for 1 month Intervention group: Medroxyprogesterone 10 mg daily for one month Intensity of hot flashes. Timepoint: Before and one month after the intervention. Method of measurement: cooperman questionnaire. Sweating rate. Timepoint: Before and one month after the intervention. Method of measurement: Questionnaire. Karaj University of Medical Sciences Approved 2021-01-19 Ethics committee of Alborz University of Medical Sciences Ethics committee unit; Vice Chancellor for Research; No.20; Saffarian alley; 45 Metri Golshahr street Karaj Alborz Iran (Islamic Republic of)