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IRCT20191106045356N2 IRCT 2021-04-18 Yazd University of Medical Sciences evaluation of the effects of Ascorbic acid on attenuation of the statin induced myopathy Clinical evaluation of the effects of Ascorbic acid on attenuation of the statin induced myopathy: a randomized double blinded placebo-controlled clinical trial 2021-05-20 anticipated 40 Complete https://irct.ir/trial/55449 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization is performed based on the RND function of Excel software and patients are divided into two groups A and B. The drug and placebo are uniform and coded in terms of the shape of the drug and the drug container, and the patient and the physician prescribing the drug and the evaluator do not know the composition and content of each drug container, Blinding description: Different groups of drugs are placed in uniform and coded containers, and the prescribing physician and the evaluator do not know the composition and content of each drug container. 3 Myopathy. Intervention 1: Includes 20 patients who are randomly selected based on the RND() function of Excel software. Patients receive two 500 mg of vitamin C capsules daily made by an Iranian pharmaceutical company for 14 days, and on days 1 and 14, 24 hours after cardiac rehabilitation exercise, using a blood test for creatine kinase, lactate dehydrogenase and aldolase enzymes are measured. Intervention 2: Includes 20 patients who are randomly selected based on the RND() function of Excel software. Patients receive two starch capsules daily for 14 days, and on days 1 and 14, 24 hours after cardiac rehabilitation exercise, using a blood test for creatine kinase, lactate dehydrogenase and aldolase enzymes are measured. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Dr. Mohsen Zabihi
Alem sq.
Yazd Iran (Islamic Republic of) 8915173149 +98 35 3820 3419 mzabihi100@gmail.com Yazd University of Medical Sciences scientific Dr. Mohsen Zabihi
Alem sq.
Yazd Iran (Islamic Republic of) 8915173149 +98 35 3820 3419 mzabihi100@gmail.com Yazd University of Medical Sciences Iran (Islamic Republic of) People between 80-30 years old Patients undergoing exercise for cardiac rehabilitation Daily intake of 40 mg of atorvastatin Maximum weight 80 kg Non-pregnancy of women The patient should not have severe peptic ulcer 30 years 80 years Both Vitamin C intolerance Do not take medication for more than two consecutive days Do not take atorvastatin for more than two consecutive days The patient becomes pregnant G72.0 Drug-induced myopathy Treatment - Drugs Treatment - Drugs Includes 20 patients who are randomly selected based on the RND() function of Excel software. Patients receive two 500 mg of vitamin C capsules daily made by an Iranian pharmaceutical company for 14 days, and on days 1 and 14, 24 hours after cardiac rehabilitation exercise, using a blood test for creatine kinase, lactate dehydrogenase and aldolase enzymes are measured. Includes 20 patients who are randomly selected based on the RND() function of Excel software. Patients receive two starch capsules daily for 14 days, and on days 1 and 14, 24 hours after cardiac rehabilitation exercise, using a blood test for creatine kinase, lactate dehydrogenase and aldolase enzymes are measured. Creatine kinase, aldolase and lactate dehydrogenase levels. Timepoint: Evaluation of patient tests on days 1 and 14 of the intervention. Method of measurement: Patient blood test and measurement of creatine kinase, aldolase and lactate dehydrogenase using relevant kits. Yazd University of Medical Sciences Approved 2021-03-21 Ethics committee of Shahid Sadoughi University of Medical Sciences Alem sq. Yazd Yazd Iran (Islamic Republic of)