IRCT20180528039883N3 IRCT 2021-08-09 Iran University of Medical Sciences Evaluation of the effect of corticosteroid injection in knee replacement Evaluation of the effect of corticosteroid injection on respiratory indices and vital signs after cement use in knee replacement 2021-06-21 anticipated 200 Complete https://irct.ir/trial/55410 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: After selecting the participants in the study using inclusion and non-inclusion criteria, to prevent the occurrence of bias in the selection of participants to intervention and control groups, we will use the randomization method to minimize the opinion of researchers in selecting participant to study groups. The block randomization method was used in this study. The size of the blocks is considered to be four and will be selected randomly so that it is not predictable to the participants based on the blocks. First, we will receive using Random Allocation software and by determining the sample size, the number of groups, the type of randomization and is random the order of the blocks in the software output and will be shown in the software output of groups with letters A and B. Then, after selecting each patient based on the inclusion and non-inclusion criteria, the project manager will be informed and he will tell the type of intervention of that patient based on the order of inclusion of patients and compliance with the number mentioned in the randomization output, Blinding description: In the present study, the surgeon will be aware of the type of intervention performed, but the analyst and patients will not be aware of the type of intervention. The information of all patients is reviewed and recorded in the file by the anesthesia technician during the surgery and after the surgery in the recovery room, and by the nurse after the transfer to the ward who is different depending on the work shift and does not know the type of intervention. Then, after the patient's discharge, the information is recorded in the checklist by a person who knows the type of intervention. 3 Bone Cement Implantation Syndrome. Intervention 1: Intervention group: One venous infusion of one 100 mg/2 ml ampoule of ABURAIHAN Co. hydrocortisone during the cement implantation. Intervention 2: Control group: No venous injection of hydrocortisone during the cement implantation. Yes - There is a plan to make this available What will be shared: It is possible to share some of the data related to the main outcomes and medical history of the study participants, but information that in any way identifies the study participants will not be available at all. When: Starting the access period after printing the results To whom: The data will only be made available to researchers at academic centers Conditions: If people request further studies on the data, they can contact the project manager Where to obtain: Applicants are required to contact the research project manager How to obtain: After reviewing the application and the academic environment, the applicant will be provided with the data. Comments: