IRCT20201204049599N4 IRCT 2021-05-15 Oroumia University of Medical Sciences Evaluation of the effect of promethazine prescription on improving endoscopy Evaluation of the promethazine prescription effect on sedation, nausea reduction and quality of the upper Esophageal gastro Endoscopy 2021-05-05 anticipated 22 Complete https://irct.ir/trial/55271 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be divided into intervention or control groups by the randomization method with a table of random numbers. First, patients will be given a code from 01 to 22. Then a number will be randomly selected from the table and will be continued from top to bottom in the table to complete the sample size. The duplicate number will be ignored and another number from the table will be checked. Numbers 01 to 11 and 11 to 22 will be assigned to the intervention group and control group, respectively, Blinding description: The study will be double-blind. The patient and the endoscopist will be blind that which groups each patient belongs to. The amount, color, and even taste of promethazine and glucose syrup will be given equally to patients in both groups. In the intervention group, 30 cc of promethazine syrup is added into 70 cc of drinking water, one hour before the endoscopy will be given to the patient by someone other than the endoscopist. In the control group, 50 g of sugar is dissolved in 100 cc of drinking water. It will be given to the patients one hour before endoscopy after adding five cc of cherry juice (to match the color and taste of promethazine syrup). 3 Upper gastrointestinal endoscopy. Intervention 1: Intervention group: In the intervention group, 30 cc of promethazine syrup in 100 cc of drinking water made by Emad Darman Pars Pharmaceutical Company (1mg /1cc ) will be given to the patient one hour before endoscopy by someone other than the endoscopist. Intervention 2: Control group: Patients will be given a solution of 50 g of glucose in 100 cc of drinking water half an hour before the upper gastrointestinal endoscopy. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information provided