IRCT20210310050669N1 IRCT 2021-03-14 Mashhad University of Medical Sciences Effect of Crocin on macular and optic nerve head vascular density in non-proliferative diabetic retinopathy Effect of Crocin on macular and optic nerve head vascular density in non-proliferative diabetic retinopathy patient with non-central macular involvement 2021-03-17 anticipated 24 Complete https://irct.ir/trial/54970 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization For each tablet container, four-digit codes will be randomly labeled to each box by pharmacist . The therapist will give it to the patient randomly without knowledge of the type of medicine. Thus, the nature of each code will be unclear until the analysis of the results, Blinding description: Crocin and placebo tablets will be prepared in a similar shape, color, and size, stored in a dark container and coded by a pharmacist. The treating physician, researcher, and patients will not be aware of the code printed on the container. 2-3 Diabetic Retinopathy. Intervention 1: Intervention group: Receiving one tablet of Crocin (15 mg)daily for 3 months. Intervention 2: Control group: Receiving one tablet of placebo daily for three months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more info