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IRCT201410285140N14 IRCT 2017-04-19 Vice chancellor of research-Faculty of Medicine-Tehran University of Medical Sciences Fluid therapy in Thyroidectomy Surgery Comparison of the effect of fluid therapy based on plethysmographic Variability Index (PVI) and conventional method on postoperative lactate levels in patients undergoing thyroidectomy surgery 2017-05-05 anticipated 50 Complete https://irct.ir/trial/5480 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Fluid Therapy. Intervention 1: In group A: During surgery once PVI > 13 %, a 250 mL crystalloid is infused and repeated for every 5 minutes up to three times. Intervention 2: In group B: 4-8 mL/kg/h crystalloid fluid infusion is maintained, and quick fluid infusion is initiated if mean arterial blood pressure (MAP) < 65 mmHg.
public Dr Ali Movafegh
Dr. Shariati Hospital, North Kargar Ave, Amir Abad, Tehran
Tehran Iran (Islamic Republic of) +98 21 8490 2282 movafegh@sina.tums.ac.ir Professor of Anesthesiology, Dr shariati Hospital scientific Dr Ali Movafegh
Dr. Shariati Hospital, North Kargar Ave, Amir Abad, Tehran
Tehran Iran (Islamic Republic of) +98 21 8490 2282 movafegh@sina.tums.ac.ir Department of Anesthesiology, Tehran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Patients aged 18 to 60 years; American Society of anesthesiologists physical status class I and II; A body mass index (BMI) less than 30 kilograms per cubic meter. Exclusion criteria: History of systemic (cardiovascular, renal, hepatic, or vascular) disorders; Inadequate peripheral intravenous access; Prolonged surgery (longer than 3 hours);intraoperative dysrhythmias; 18 years 60 years Both R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis Treatment - Drugs Treatment - Drugs In group A: During surgery once PVI > 13 %, a 250 mL crystalloid is infused and repeated for every 5 minutes up to three times. In group B: 4-8 mL/kg/h crystalloid fluid infusion is maintained, and quick fluid infusion is initiated if mean arterial blood pressure (MAP) < 65 mmHg. Amounts of lactate in fluid therapy according to PVI (plethysmographic variation Index). Timepoint: On admission as well as at the end of surgery. Method of measurement: Millimole/liter , Enzymatic. Total amount of intraoperative fluids infused after fluid therapy according to conventional method. Timepoint: End of surgery. Method of measurement: Milliliter. Amounts of lactate in fluid therapy according to conventional method. Timepoint: on admission as well as at the end of surgery. Method of measurement: Millimole/liter, Enzymatic. Mean arterial pressure during fluid therapy according to conventional method. Timepoint: Before anesthesia as well as 1, 2, 3, and 5 minutes after that. Method of measurement: Using patients monitoring - millimeter of mercury. Total amounts of Urine output after fluid therapy according to conventional method. Timepoint: End of surgery. Method of measurement: Milliliter. Vice chancellor of research-Faculty of Medicine-Tehran University of Medical Sciences Approved 2016-10-29 Ethic Committee, Faculty of Medicine of Tehran University of Medical Sciences Research Deputy, Ethics Committee of Tehran University of Medical Sciences, 6th floor, Tehran University of Medical Sciences building, Ghods St, Keshavarz Blvd Tehran Iran, Islamic Republic Of Tehran Iran (Islamic Republic of)