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IRCT201701095138N3 IRCT 2017-02-14 Vice Chancellor for Research of Mazandaran University of Medical Sciences Effectiveness of transcranial Direct Current Stimulation (tDCS) in Obsessive-Compulsive Disorder patients Comprative effectiveness of transcranial Direct Current Stimulation (tDCS) in both PreSMA and LOF inhibition and comparing them with placebo in reducing symptoms in nonresponsive OCD patients 2016-12-21 anticipated 51 Complete https://irct.ir/trial/5467 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Obsessive-Compulsive Disorder. Intervention 1: 17 patient in 10 days and every day 20 min treated with tDCS that cathode on left orbitofrontal region and anode on contralateral region with intensity 2mA. Intervention 2: 17 patient in 10 days and every day 20 min treated with tDCS that cathode on left presupplementary motor area and anode on contralateral region with intensity 2mA. Intervention 3: 17 patient in 10 days and every day 20 second treated with tDCS that cathode on left orbitofrontal region and anode on contralateral region with intensity 2mA.
public Mohammad Mehdi Rezaei
Zare Hospital Sari-Neka Road
Sari Iran (Islamic Republic of) +98 11 3328 3886 drrezaei@hotmail.com Mazandaran University of Medical Sciences scientific Dr. Abbas Masoudzadeh
Zare Hospital Sari-Neka Road
Sari Iran (Islamic Republic of) +98 11 3328 3886 amasoudzadeh@mazums.ac.ir Mazandaran University of Medical Scienses Iran (Islamic Republic of) Inclusion criteria: Diagnosis of OCD according to DSMV ; Lack of response to treatment with 2 drugs with sufficient dose and time (equal 80 mg Fluoxetine) ; Only this diagnosis in axis I and not have diagnosis in axis II ; Lack of drug dependence and lack of major neurological complications in terms of history; Written consent to participate in the study ; Right-handed ; Unchanged drug in the last month and the lack of psychotherapy in 8 weeks Exclusion criteria:Other disorders in axis I and II ; Having implant or prosthesis or metal in skull ; Patient satisfaction or waiver of him; Pregnancy 18 years 60 years Both F 42.0 These may take the form of ideas, mental images, or impulses to act, which are nearly always distressing to the subject. Sometimes the ideas are an indecisive, endless consideration of alternatives, associated with an inability to make trivial but necessa Treatment - Devices Treatment - Devices Placebo 17 patient in 10 days and every day 20 min treated with tDCS that cathode on left orbitofrontal region and anode on contralateral region with intensity 2mA 17 patient in 10 days and every day 20 min treated with tDCS that cathode on left presupplementary motor area and anode on contralateral region with intensity 2mA 17 patient in 10 days and every day 20 second treated with tDCS that cathode on left orbitofrontal region and anode on contralateral region with intensity 2mA Intensity of Obsession Compulsion Symptoms. Timepoint: Before intervention- after last intervention and 1 month after last intervention. Method of measurement: YALE-BROWN (Y-BOCS) Test. Vice Chancellor for Research of Mazandaran University of Medical Sciences Approved 2017-01-17 Ethics Committee of Mazandaran University of Medical Sciences Moallem Sq. Sari Iran (Islamic Republic of)