IRCT20210220050430N1 IRCT 2021-05-07 Iran University of Medical Sciences The effect of oral L-arginine supplementation on improvement of cardiovascular function and pulmonary artery pressure in patients with major and Intermedia beta-thalassemia The effect of oral L-arginine supplementation on improvement of cardiovascular function and pulmonary artery pressure in patients with major and Intermedia beta-thalassemia 2021-05-20 anticipated 88 Complete https://irct.ir/trial/54556 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Random sampling is simple in that the names of all patients of thalassemia over 15 years is written and 88 people, which is equivalent to the sample size, will be selected by lot and Permuted- Block randomization are divided into two groups 8 blocks consisting of 4 participants in the intervention group and 4 participants in the control group. Block randomization is one of the limited randomization methods and is a Double-blind study, Blinding description: In this study, the drug and placebo were labeled by the manufacturer Group A and Group B. Which are quite similar in appearance and the person participating in the study and the person distributing the medicine does not know about this labeling. 3 Betha thalasemia. Intervention 1: Intervention group: Give oral vial L-arginine supplement made by iranian bio fermentation company with dose 0.1 gr /kg divided 2 or 3 time for 8 weeks. Intervention 2: Control group: give oral vial placebo made by iranian bio fermentation company similer to the main drug contain oral glucose for 8 week. No - There is not a plan to make this available Justification or reason for not sharing IPD is Confidentiality of patient information