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IRCT20140109016151N9 IRCT 2021-03-12 Iran University of Medical Sciences Comparison of effectiveness and speed of shivering treatment after general anesthesia with pethidine and doxapram. Comparison of the effectiveness and speed of shivering treatment after general anesthesia with pethidine and doxapram in patients undergoing orthopedic surgery and urological surgery referred to Firoozgar Hospital in Tehran. 2020-08-22 anticipated 56 Complete https://irct.ir/trial/54424 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, we use the block randomization method so that after selecting patients according to the inclusion and exclusion criteria by selecting numbers from the table of random numbers and adapting to the blocks, patients are divided into study groups.To randomize the two treatment methods, we create 4 blocks in six different states, then select a number using the table of numbers, and determine the study groups by matching the numbers with the blocks. For example, if the first digit of our number is 1 to 6, select a block and the division is done, but if, for example, our number is 94071, the digit 9 is not valid and we select the next digit. Here, based on the block, we divide 4 people into groups. 1. TTCC 2. TCTC 3. TCCT 4. CCTT 5. CTCT 6. CTTC, Blinding description: In this study, people who are responsible for patient care and analysis of statistical data do not know about the treatment process and study groups, and information is provided to them in groups A and B. 3 orthopedic surgery. Intervention 1: Intervention group: Patients who have not responded to non-pharmacological treatment of chills after surgery and are injected with pethidine made by Caspian Pharmaceutical Company (50 mg ampoule per cc) .To treat chills, 25 mg of pethidine is injected in a single dose. Intervention 2: Intervention group: Patients who did not respond to non-pharmacological treatment of shivering after surgery were injected with doxapram, a Caspian drug company based on weight. According to the treatment protocol, the dose of doxapram is 0.7mg / kg. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.
public Alireza Pournajafian
Fifth floor, Central staff, Iran University of Medical Sciences, Hemmat Highway
Tehran Iran (Islamic Republic of) 8874113911 +98 21 8894 6762 a-pournajafian@tums.ac.ir Iran University of Medical Sciences scientific Alireza Pournajafian
Anesthesia Department, Firouzgar Hospital ,Beh-afarin street
Tehran Iran (Islamic Republic of) 8874113911 +98 21 8894 6762 a-pournajafian@tums.ac.ir Iran University of Medical Sciences Iran (Islamic Republic of) Patients with ASA I, II anesthesia level Patients aged 20 to 60 years undergoing orthopedic and urological surgery Surgery less than 4 hours 20 years 60 years Both History of lung disease Drug allergy to pethidine or doxapram M96.62 Fracture of humerus following insertion of orthopedic implant, joint prosthesis, or bone plate Treatment - Drugs Treatment - Drugs Intervention group: Patients who have not responded to non-pharmacological treatment of chills after surgery and are injected with pethidine made by Caspian Pharmaceutical Company (50 mg ampoule per cc) .To treat chills, 25 mg of pethidine is injected in a single dose. Intervention group: Patients who did not respond to non-pharmacological treatment of shivering after surgery were injected with doxapram, a Caspian drug company based on weight. According to the treatment protocol, the dose of doxapram is 0.7mg / kg. Shivering after surgery. Timepoint: After surgery. Method of measurement: observation. Hypoxia. Timepoint: After surgery. Method of measurement: Pulse oximeter. Iran University of Medical Sciences Approved 2020-08-09 Ethics committee of Iran University of Medical Sciences Fifth floor, Central staff, Iran University of Medical Sciences, Hemmat Highway Tehran Tehran Iran (Islamic Republic of)