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IRCT20191106045356N6 IRCT 2021-07-29 Yazd University of Medical Sciences The effect of curcumin on the prevention of paclitaxel and platinum compounds-induced neuropathy in cancer patients The effect of curcumin on the prevention of paclitaxel and platinum compounds-induced neuropathy in cancer patients: a randomized double-blinded controlled clinical trial 2021-05-22 anticipated 35 Complete https://irct.ir/trial/54373 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Curcumin and placebo are uniformly divided into two groups of drug containers that are labeled A or B in terms of the shape of the drug and the container containing the drug. In such a way that the doctor and the patient do not know the type of medicine in each medicine container. Patients who meet the inclusion criteria receive one of the drugs labeled A or B based on the RND() function of Excel software and take one number daily for 42 days, and they are evaluated during and after the intervention, Blinding description: The medicine and placebo are placed in uniform containers and the doctor and the patient do not know the type of medicine prescribed in each group. 3 Chemotherapy induced neuropathy. Intervention 1: Intervention group: Daily recipient of 80 mg of oral curcumin from Sina Droo Pharmaceutical Company with Sina Curcumin brand for 28 days. Patients are evaluated for neuropathy on days 1, 4, 7, 14and 28. Intervention 2: Control group: Daily recipient of one oral capsule containing starch as placebo from Pharmacy school for 28days. Patients are evaluated for neuropathy on days 1, 4, 7, 14and 28. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Dr. Mohsen Zabihi
Alem sq.
Yazd Iran (Islamic Republic of) ۸۹۱۵۱۷۳۱۴۹ +98 35 3820 3419 mzabihi100@gmail.com Yazd University of Medical Sciences scientific Dr. Mohsen Zabihi
Alem sq.
Yazd Iran (Islamic Republic of) ۸۹۱۵۱۷۳۱۴۹ +98 35 3820 3419 mzabihi100@gmail.com Yazd University of Medical Sciences Iran (Islamic Republic of) Age 20-50 years Initiation of the treatment with paclitaxel and platinum compounds in cancer patients 20 years 50 years Both History of allergy to curcumin or turmeric Having diseases that cause neuropathy such as diabetes or conditions such as alcoholism. Prevention Prevention Intervention group: Daily recipient of 80 mg of oral curcumin from Sina Droo Pharmaceutical Company with Sina Curcumin brand for 28 days. Patients are evaluated for neuropathy on days 1, 4, 7, 14and 28 Control group: Daily recipient of one oral capsule containing starch as placebo from Pharmacy school for 28days. Patients are evaluated for neuropathy on days 1, 4, 7, 14and 28 The neuropathy score is determined based on the Michigan Neuropathy Screening Instrument (MNSI) questionnaire, which includes a test with 20 yes / no questions. Timepoint: Days 1, 4, 7, 14, 28 science starting internention. Method of measurement: Patient examination and Michigan Neuropathy Screening Instrument (MNSI) questionnaire. Yazd University of Medical Sciences Approved 2021-06-30 Ethics committee of ُ Shahid Sadoughi University of Medical Sciences Alem sq. Yazd Yazd Iran (Islamic Republic of)