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IRCT20210214050352N1 IRCT 2021-08-04 Arak University of Medical Sciences The effect of antibiotic lock on catheter persistence in hemodialysis patients The evaluation of efficacy of antibiotic lock accompanied by systemic antibiotic therapy in permanent haemodialysis by probability of catheter infection on the rate of infection of the catheter 2021-03-05 anticipated 60 Complete https://irct.ir/trial/54368 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be divided into two groups using block randomization method. In this way, before performing the disease, random block sequences will be created using the online software sealedenvelope.com and in 10 sequences of 6. The created sequences will then be placed in dark and sealed envelopes and the sequences will be numbered, respectively, and the disease will be treated using the created sequences, respectively, Blinding description: This study was performed as a one-sided blind and the blinding will be done in such a way that the participating patients are not aware of the study groups and the type of their intervention and the participating groups are known only by letters (A and B). The clinical caregiver and the facilitator are aware of the study groups. 3 Permi-cath infection. Intervention 1: Intervention group: 30 patients for whom standard systemic antibiotic therapy of vancomycin 7.5mg / kg as stat and ceftazidime 2 gr as stat after each dialysis will be performed by peripheral intravenous injection and antibiotic lock of permi-cath lumens will be performed by using 2 ml of hand solution Colorless instrument for each lumen, including 5 mg / ml vancomycin (Elixir-Iran), 10 mg / ml ceftazidime (Elixir-Iran) and 10000 IU / ml heparin (Pharmacopoeia-Iran), after each dialysis and until blood culture results are ready. Intervention 2: Control group: 30 patients for whom standard systemic antibiotic therapy of vancomycin 7.5mg / kg as stat and ceftazidime 2 gr as stat after each dialysis will be performed by peripheral intravenous injection and lock of permi-cath lumen will be performed by using 2 ml of solution containing 10000IU / ml of heparin (Darupakhsh-Iran), after each dialysis and until blood culture results are ready. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Ahmad Saebian
Payambar-e-azam Complex, Sardasht Town
Arak Iran (Islamic Republic of) 3848176341 +98 86 3417 3645 Ahmad.saebian@yahoo.com Arak University of Medical Sciences scientific Ahmad Saebian
Payambar-e-azam Complex, Sardasht Town
Arak Iran (Islamic Republic of) 3848176341 +98 86 3417 3645 Ahmad.saebian@yahoo.com Arak University of Medical Sciences Iran (Islamic Republic of) End stage renal disease patients whose hemodialysis is performed using permi-cath and have a fever and have been hospitalized with a possible diagnosis of an infection catheter no limit no limit Both Catheter Tunnel Infection Simultaneous infection of non-catheter origin HIV positive patients Intravenous drug users Immunodeficiency Severe sepsis T80.21 Infection due to central venous catheter Treatment - Drugs Treatment - Drugs Intervention group: 30 patients for whom standard systemic antibiotic therapy of vancomycin 7.5mg / kg as stat and ceftazidime 2 gr as stat after each dialysis will be performed by peripheral intravenous injection and antibiotic lock of permi-cath lumens will be performed by using 2 ml of hand solution Colorless instrument for each lumen, including 5 mg / ml vancomycin (Elixir-Iran), 10 mg / ml ceftazidime (Elixir-Iran) and 10000 IU / ml heparin (Pharmacopoeia-Iran), after each dialysis and until blood culture results are ready. Control group: 30 patients for whom standard systemic antibiotic therapy of vancomycin 7.5mg / kg as stat and ceftazidime 2 gr as stat after each dialysis will be performed by peripheral intravenous injection and lock of permi-cath lumen will be performed by using 2 ml of solution containing 10000IU / ml of heparin (Darupakhsh-Iran), after each dialysis and until blood culture results are ready. Fever. Timepoint: Every 8 hours. Method of measurement: Mercury Therommeter. Leukocytosis. Timepoint: Daily. Method of measurement: Blood cell counter. Duration of hospitalization. Timepoint: When discharged from the hospital. Method of measurement: Based on hospitalization file. Arak University of Medical Sciences Approved 2021-05-30 Ethics committee of Arak University of Medical Sciences Payambar-e-azam Complex, Sardasht Town Arak Markazi Iran (Islamic Republic of)