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IRCT20210212050332N1 IRCT 2021-02-16 Riphah International University (RARE) Effect on coconut oil, moringaoleifera and chlorhexidine on oral health. Comparison of antimicrobial properties of coconut oil, moringa oleifera and chlorhexidine on oral bacterial populations 2021-06-22 anticipated 90 Complete https://irct.ir/trial/54269 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 1 Condition 1: Caries. Condition 2: Periodontitis. Intervention 1: Intervention group: (Coconut oil). 30 individuals in this group will be sampled from the sub gingival area of the lingual surfaces of lower central incisors. The plaque and gingival crevicular fluid collected will be sent for detailed microbiologic analysis (PCR, biochemical testing, bacterial culture). All individuals will be given an emulsion of non-hydrogenated coconut oil as a mouthwash. The participant will be requested to rinse with 15 mL emulsion twice daily. On day 14, the participant will be undergo microbiologic analysis again from the same site. Intervention 2: Intervention group: (Moringa Oleifera). 30 individuals in this group will be sampled from the sub gingival area of the lingual surfaces of lower central incisors. The plaque and gingival crevicular fluid collected will be sent for detailed microbiologic analysis (PCR, biochemical testing, bacterial culture). All individuals will be given a mouthwash made with moringa oleifera extract. The participant will be requested to rinse with 15 mL solution twice daily. On day 14, the participant will be undergo microbiologic analysis again from the same site. Intervention 3: Control group: (Chlorhexidine gluconate). Chlorhexidine gluconate is a gold standard antibacterial for the oral cavity. This is why it will be used in the control group to compare the efficacy of gold standard against the coconut oil and moringa oleifera mouthwashes. 30 individuals in this group will be sampled from the sub gingival area of the lingual surfaces of lower central incisors. The plaque and gingival crevicular fluid collected will be sent for detailed microbiologic analysis (PCR, biochemical testing, bacterial culture). All individuals will be given a 0.2% chlorhexidine. The participant will be requested to rinse with 15 mL solution twice daily. On day 14, the participant will be undergo microbiologic analysis again from the same site. Yes - There is a plan to make this available What will be shared: All collected deidentified IPD will be submitted. When: The data will be made available following completion of the project for a 4 week period. To whom: Data sharing will be open to all. Conditions: The primary investigator will decide on who to release data to. Where to obtain: Email requests will be accommodated. How to obtain: An email request needs to be sent to the principal investigator. Comments:
public Amber Kiyani
7th Avenue, G-7/4
Islamabad Pakistan 44000 +92 51 2891835 akiyani@gmail.com Riphah International University scientific Amber Kiyani
Riphah International University, 7th Avenue, G-7/4
Islamabad Pakistan 44000 +92 51 2891835 akiyani@gmail.com Riphah International University Pakistan Good oral hygiene. Good brushing habits. 18 years 40 years Both Periodontal disease. Systemic disease affecting periodontal health. Recent history of oral prophylaxis. Recent history of antibiotic use. K02.9 K05.6 Dental caries, unspecified Periodontal disease, unspecified Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: (Coconut oil). 30 individuals in this group will be sampled from the sub gingival area of the lingual surfaces of lower central incisors. The plaque and gingival crevicular fluid collected will be sent for detailed microbiologic analysis (PCR, biochemical testing, bacterial culture). All individuals will be given an emulsion of non-hydrogenated coconut oil as a mouthwash. The participant will be requested to rinse with 15 mL emulsion twice daily. On day 14, the participant will be undergo microbiologic analysis again from the same site. Intervention group: (Moringa Oleifera). 30 individuals in this group will be sampled from the sub gingival area of the lingual surfaces of lower central incisors. The plaque and gingival crevicular fluid collected will be sent for detailed microbiologic analysis (PCR, biochemical testing, bacterial culture). All individuals will be given a mouthwash made with moringa oleifera extract. The participant will be requested to rinse with 15 mL solution twice daily. On day 14, the participant will be undergo microbiologic analysis again from the same site. Control group: (Chlorhexidine gluconate). Chlorhexidine gluconate is a gold standard antibacterial for the oral cavity. This is why it will be used in the control group to compare the efficacy of gold standard against the coconut oil and moringa oleifera mouthwashes. 30 individuals in this group will be sampled from the sub gingival area of the lingual surfaces of lower central incisors. The plaque and gingival crevicular fluid collected will be sent for detailed microbiologic analysis (PCR, biochemical testing, bacterial culture). All individuals will be given a 0.2% chlorhexidine. The participant will be requested to rinse with 15 mL solution twice daily. On day 14, the participant will be undergo microbiologic analysis again from the same site. Oral microbial populations. Timepoint: 2 weeks. Method of measurement: Culture, PCR, biochemical methods. Riphah International University (RARE) Approved 2017-10-06 Institutional Review Committee, Riphah International University Riphah International University, Islamic International Dental College, 7th Avenue, G-7/4 Islamabad Federal Pakistan