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IRCT20160523028008N11 IRCT 2021-02-20 Hamedan University of Medical Sciences Transcranial Magnetic Stimulation ( rTMS ) add-on therapy to Standard treatment in Multiple sclerosis Patients with Depression Symptoms Effectiveness of Repetitive Transcranial Magnetic Stimulation ( rTMS ) add-on therapy to Standard treatment in Multiple sclerosis Patients with Depression Symptoms in Sina Farshchian Hospital in Hamadan city 2021-04-21 anticipated 40 Complete https://irct.ir/trial/54245 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The patients will be randomly assigned to intervention and control groups using block randomization. For this purpose, we will prepare four sheets of paper, writing on two sheets the name of the intervention and on the other two sheets the name of the control. The paper sheets will be pooled, placed in a container, and randomly drawn one at a time for each patient without replacement until all four sheets are drawn. The four paper sheets will be then placed back into the container, and this action repeated until the sample size is reached, Blinding description: According to the intervention, patients do not know about the assignment of the group, so a one-way blind study is performed. 2-3 Multiple Sclerosis. Intervention 1: Intervention group: 10 session of 20 minute of trans cranial direct current stimulation by 2 ma. Intervention 2: Control group: 10 inactive session of 20 minutes by the same deviceCategoryOther. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is not a plan to make this available
public Amir Keshavarzi
Farshchian Hospital, Mirzadeh Eshghi Ave.
Hamadan Iran (Islamic Republic of) 6517838695 +98 81182851015 drkeshavarzi@yahoo.com Hamedan University of Medical Sciences scientific Amir Keshavarzi
Farshchian Hospital, Mirzadeh Eshghi Ave.
Hamadan Iran (Islamic Republic of) 6517838695 +98 81182851015 drkeshavarzi@yahoo.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Satisfaction to participate in the study Patient with multiple sclerosis of any type and with moderate and high depression Not receive repeated transcranial magnetic stimulation and electroconvulsive therapy in the past two months 18 years no limit Both Having a shunt and any other metal object near the head Interferon consumption Pregnant or lactating women Patients at risk of suicide Patients with other psychiatric disorders such as bipolar disorder G35 Demyelinating diseases of the central nervous system Treatment - Other Treatment - Other Intervention group: 10 session of 20 minute of trans cranial direct current stimulation by 2 ma Control group: 10 inactive session of 20 minutes by the same deviceCategoryOther Depression rate. Timepoint: before and after 10 sessions of intervention. Method of measurement: Montgomery-Asberg Depression Rating Scale (MADRS). Fatigue severity test. Timepoint: before and after 10 sessions of intervention. Method of measurement: Fatigue Severity Scale. Expanded Disability Status Scale. Timepoint: before and after 10 sessions of intervention. Method of measurement: Expanded Disability Status Scale. Cognitive Assessment. Timepoint: before and after 10 sessions of intervention. Method of measurement: Montreal Cognitive Assessment. Hamedan University of Medical Sciences Approved 2021-01-30 Research Ethic Committee of Hamadan University of Medical Sciences Vice-chancellor of Research the Technology, Hamadan University of Medical Sciences, Shahid Fahmideh Ave Hamadan Hamadan Iran (Islamic Republic of)