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IRCT20160516027929N11 IRCT 2021-09-25 Shahid Beheshti University of Medical Sciences Comparison of the efficacy and side effects of desloratadine with fexofenadine on allergic rhinitis in patients referred to Masih Daneshvari Hospital Comparison of the efficacy and side effects of desloratadine with fexofenadine on allergic rhinitis in patients referred to Masih Daneshvari Hospital 2021-04-04 anticipated 65 Complete https://irct.ir/trial/54017 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization method: simple randomization, randomization unit: individual, randomization tool: table of random numbers, To construct a random sequence with the help of a random number table and by the statistical consultant, patients accidentally had one of the even and odd codes. Patients who were assigned even numbers were in the first group and patients with odd codes were in the second group, Blinding description: The drugs are placed in bags that are similar in appearance and are labeled as groups A and B. The patient is unaware of this labeling (aware of receiving medication but kept blind to group assignments). Also, the project partner who distributes the medicine is not aware of this labeling. To avoid any possible complications, the lead researcher is aware of the assignment of groups. 2 Allergic rhinitis. Intervention 1: Intervention group: In the first group, patients receive 5 mg of desloratadine daily for 4 weeks.After 2 weeks of no drug treatment, they are treated with fexofenadine 120 mg daily for 4 weeks. Intervention 2: Intervention group: In the second group, patients received 120 mg of fexofenadine daily for 4 weeks. After two weeks of no drug treatment, they are treated with desloratadine. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is currently no program
public Atefeh Fakharian
(Niavaran), Darabad, Shahid Bahonar St.
: Tehran Iran (Islamic Republic of) 1956944413 +98 21 2610 5050 fakharian_2005@yahoo.com Shahid Beheshti University of Medical Sciences scientific Atefeh Fakharian
(Niavaran), Darabad, Shahid Bahonar St.
Tehran Iran (Islamic Republic of) 1956944413 +98 21 2610 5050 fakharian_2005@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Age over 12 years History of allergic rhinitis or diagnosis at first visit Written consent to participate in the study 12 years no limit Both Sensitivity, allergy or adverse reaction to desloratadine and fexofenadine Patients who have previously been treated with two or more drugs pregnancy and breastfeeding J30.1 Allergic rhinitis due to pollen Treatment - Drugs Treatment - Drugs Intervention group: In the first group, patients receive 5 mg of desloratadine daily for 4 weeks.After 2 weeks of no drug treatment, they are treated with fexofenadine 120 mg daily for 4 weeks. Intervention group: In the second group, patients received 120 mg of fexofenadine daily for 4 weeks. After two weeks of no drug treatment, they are treated with desloratadine. General clinical symptoms. Timepoint: Before starting treatment and 10 weeks after starting treatment. Method of measurement: Rhinitis Quality of Life Questionnaire. The severity of eye symptoms. Timepoint: Rhinitis Quality of Life Questionnaire. Method of measurement: Rhinitis Quality of Life Questionnaire. Severe itching in the nose. Timepoint: Rhinitis Quality of Life Questionnaire. Method of measurement: Rhinitis Quality of Life Questionnaire. Sleep disorders. Timepoint: Rhinitis Quality of Life Questionnaire. Method of measurement: Rhinitis Quality of Life Questionnaire. Evaluation of the clinical symptoms of allergic rhinitis. Timepoint: Before starting treatment and 10 weeks after starting treatment. Method of measurement: Physical examination. Shahid Beheshti University of Medical Sciences Approved 2020-09-22 Ethics Committee of Shahid Beheshti University of Medical Sciences Shahid Arabi St., Yemen St., Shahid Chamran Highway Tehran Tehran Iran (Islamic Republic of)