IRCT20120215009014N377 IRCT 2021-01-25 Hamedan University of Medical Sciences Effect of the N-acetyl cysteine versus placebo on prevention and control of chemotherapy induced neuropathy in patients with breast cancer Effect of the N-acetyl cysteine versus placebo on prevention and control of chemotherapy induced neuropathy in patients with breast cancer: a triple-blind randomized clinical trial 2021-02-03 anticipated 102 Complete https://irct.ir/trial/53874 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random assignment of the patients to the intervention and control groups through the drawing of lots. To do this, we prepare two sheets and write "intervention" on one sheet and "control" on another. Then, by referring each patient, one of the sheets will be randomly taken and the patient will be assigned to the intervention or control group, Blinding description: The shape of the medications and placebos will be perfectly the same. Therefore, patients will be unaware of the type of intervention. The care provider who will deliver the medications and the physician who will examine the patients will not be aware of the intervention. The analyzer will be unaware of the type of interventions. Thus, the trial will be run as triple-blind. 3 Neuropathy. Intervention 1: Intervention group: tablet N-acetyl cysteine (manufactured by Darman Yab Daru Pharmaceutical Co.) 1200 mg twice daily one day before chemotherapy with Taxane untile one day after that. Intervention 2: Control group: tablet placebo (manufactured by School of Pharmacy, Shahid Beheshti University of Medical Science) twice daily one day before chemotherapy with Taxane until one day after that. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situations and the results of the study as well as the approval of the financial supporting organization.