IRCT20210118050067N1 IRCT 2021-02-16 Esfahan University of Medical Sciences effect of 5-fu and rosemary extract polymeric wound dressing A Comparative study of the effect of nanofibers containing 5% 5-Fluorouracil and rosemary extract and nanofibers containing 5% 5-Fluorouracil and 5% 5-Fluorouracil cream on Actinic Keratosis Lesions Treatment 2021-02-19 anticipated 15 Complete https://irct.ir/trial/53762 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization with the table of random number, Blinding description: A non-blinded dermatologist (investigator) evaluates the patients before treatment, reaching the clinical diagnosis of actinic keratosis. The dermatologist determines lesions and their location through the photographic image. The same dermatologist evaluates the patients 2 weeks after treatment and verify the presence of adverse effects. The dermatologist also records new photographic images (under the same conditions of light and distance that the first ones were taken) evaluating the improvement of the lesions according to the Investigator Global Improvement Score and the patient’s degree of satisfaction through the visual analog scale Score. A blinded dermatologist evaluate the photographs and rate the improvement of the lesions through the Investigator Global Improvement Score. 2 Actinic keratosis. Intervention 1: Control group: Patients take 5% 5-fluorouracil cream from Meda Co. They take the cream every night until the next morning for 4 weeks. Intervention 2: Intervention group: Patients take the Polyvinyl alcohol nanofibers containing 5% 5-fluorouracil. They take nanofibers every night until the next morning for 4 weeks. Intervention 3: Intervention group: Patients take the Polyvinyl alcohol nanofibers containing 5% 5-fluorouracil and 5% standardized Rosemary extract. They take nanofibers every night until the next morning for 4 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.