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IRCT20210113050025N1 IRCT 2021-01-21 Sanandaj University of Medical Sciences ٍٍEffect of Hypericum Perforatum extract on tissue healing. Evaluation of effect of Hypericum Perforatum extract on soft tissue healing of tooth extraction socket. 2021-01-30 anticipated 30 Complete https://irct.ir/trial/53672 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: Participants are not informed in which direction the intervention will take place. The socket one side is randomly selected as the test area and the opposite side as the control. Be. If the selected number is even, the right side is defined as the intervention and the left side as the control, and if it is odd, the left side is defined as the intervention and the right side as the control. The dentist who puts herbal gel in the socket identifies the intervention site with a color code in the checklist. The researcher who examines the tooth socket in follow up sessions evaluate the healing process without knowing the meaning of the code. 3 postextraction socket healing. Intervention 1: Intervention group: After achieving adequate anesthesia and tooth extraction the dentist will place 2ml of 5% gel containing Hypericum Perforatum extract with the use of a syringe in the intervention side socket and then he will put a piece of gauze moistened with normal saline solution on it and ask the patient to keep the gauze piece in place for 45 min. Intervention 2: Control group: After rinsing gently with normal saline,a piece of gauze moistened with normal saline solution (NSS) will be placed on the socket wound, and the patient is asked to hold the gauze in place for 45 minutes. Yes - There is a plan to make this available What will be shared: All data is from the proposal, raw data and project reports When: Data is available from the legal system six months after publication for two years To whom: All persons will be able to access the Kurdistan University of Medical Sciences's request to the Kurdistan University of Medical Sciences. Conditions: For legal issues and the need to use data in future studies Where to obtain: Faranak Shafiei, Zahra Haghigat Pasand, Masoud Moradi How to obtain: After submitting a request to the Kurdistan Research and Technology Dept. of Science and Technology, a call for submission is Comments:
public Zahra Haghighatpasand Astaneh
Dentistry faculty, Kurdistan University of medical Sciences, Pasdaran Blvd
Sanandaj Iran (Islamic Republic of) 6617713446 +98 87 3366 4648 sogand.haqiqat76@gmail.com Sanandaj University of Medical Sciences scientific Faranak Shafiee
Densitary Faculty, Kurdistan University of medical Sciences,Pasdaran Blvd,
Sanandaj Iran (Islamic Republic of) 6617713446 +98 87 3366 4648 faranakshafiee@gmail.com Sanandaj University of Medical Sciences Iran (Islamic Republic of) People 18 to 30 years old bilateral maxillary premolars extraction for orthodontic reasons 18 years 30 years Both Pregnancy Breastfeeding Traumatic and surgical extractions History of systemic diseases and allergies Smoking Alcohol abuse History of taking corticosteroids, contraceptives and antidepressants Need to take antibiotics and NSAIDs after tooth extractions Periodontal disease, infection or any pathology at the area of the tooth indicated for extraction Need more than one carpule to create local anesthesia Who are not willing to participate during the follow ups Treatment - Drugs N/A Intervention group: After achieving adequate anesthesia and tooth extraction the dentist will place 2ml of 5% gel containing Hypericum Perforatum extract with the use of a syringe in the intervention side socket and then he will put a piece of gauze moistened with normal saline solution on it and ask the patient to keep the gauze piece in place for 45 min. Control group: After rinsing gently with normal saline,a piece of gauze moistened with normal saline solution (NSS) will be placed on the socket wound, and the patient is asked to hold the gauze in place for 45 minutes. Healing score. Timepoint: Third and seventh day after tooth extraction. Method of measurement: Healing index by Landry, Turnbull and Howley. Wound size. Timepoint: Extraction day (baseline), third and seventh day after tooth extraction. Method of measurement: Castroviejo caliper. Pain severity. Timepoint: Extraction day (baseline), third and seventh day after tooth extraction. Method of measurement: Numeric Pain Rating Scale. Sanandaj University of Medical Sciences Approved 2021-01-11 Ethics committee of Kurdistan University of medical Sciences Pasdaran ave , Kurdistan University of medical Sciences Sanandaj Kurdistan Iran (Islamic Republic of)