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IRCT20201028049175N2 IRCT 2021-01-13 Arak University of Medical Sciences Comparison of the efficacy of Atorvastatin and Rosuvastatin in atrial fibrillation incidence after coronary artery bypass graft surgery (CABG) Comparison of the efficacy of Atorvastatin and Rosuvastatin in atrial fibrillation incidence after coronary artery bypass graft surgery (CABG) 2021-03-10 anticipated 104 Complete https://irct.ir/trial/53567 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients will be allocated into two groups using a permuted balanced block randomization method with the size of blocks 4 and 6. Random sequence will be generated by an epidemiologist by running an online program in sealed envelope website (https://www.sealedenvelope.com/). Concealment is also guaranteed due to the use of specific codes that are obtained by the website, Blinding description: Patients blindness: All patients are unaware about the name of drugs and the shape and size of drugs are similar. Researcher blindness: According to doctor's prescription, drugs will be given to the patients by nurses; so researcher's doctor filled the check lists is blind about the groups. 2 Condition 1: Atrial fibrillation after CABG. Condition 2: Atrial fibrillation after CABG. Intervention 1: Intervention group:Atorvastatin 40 mg tablet orally will be used after surgery when patient can use oral nutrition, daily till 7 days after surgery. Intervention 2: Intervention group:Rosuvastatin 20 mg tablet orally will be used after surgery when patient can use oral nutrition, daily till 7 days after surgery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There are no more data.
public Alireza Kamali
Valiasr hospital, Valiasr square
Arak Iran (Islamic Republic of) 3814957558 086-32222003-8 alikamaliir@yahoo.com Arak University of Medical Sciences scientific Elham Farahani
Shahid Shiroudi street, Parastar square, Amirkabir hospital
Arak Iran (Islamic Republic of) 3814957558 08633134715-19 farahani13025@gmail.com Arak University of Medical Sciences Iran (Islamic Republic of) All of patients reffered to Amiralmomenin hospital for elective CABG surgery Patients with 40 or more than 40 EF Patients with On-pump method in surgery 18 years 80 years Both Recent MI Using of antiarhythmic drugs especially Amiodarone History of AF Valvular dysfunction Other surgeries with CABG Organic disease (i.e chronic renal failure stage 3 and 4), thyroid dysfunction, immunosuppression, cancer, central nervous system disease, brain vessels disease and history of CerebroVascular Accident, hormonal diseases, rise of liver enzymes) Hypo/hyperkalemia Dialysis (abnormal Cr) Use of anti-inflammatory drugs Psychological disorders I48.0 T82.9 Paroxysmal atrial fibrillation Unspecified complication of cardiac and vascular prosthetic device, implant and graft Treatment - Drugs Treatment - Drugs Intervention group:Atorvastatin 40 mg tablet orally will be used after surgery when patient can use oral nutrition, daily till 7 days after surgery. Intervention group:Rosuvastatin 20 mg tablet orally will be used after surgery when patient can use oral nutrition, daily till 7 days after surgery. Frequency of post CABG atrial fibrillation. Timepoint: As starting drug till 7 days after surgery. Method of measurement: Heart monitoring. Arak University of Medical Sciences Approved 2020-12-27 Ethics committee of Arak University of Medical Sciences Assistance of research and technology, Payambare azam institution, Arak University of Medical Sciences, Basij square Arak Markazi Iran (Islamic Republic of)