IRCT20130311012782N51 IRCT 2021-02-02 Esfahan University of Medical Sciences Comparison of the effect of retplasia and surgery in the treatment of infection around the pleura Comparison of the effect of Video Assisted thoracoscopic surgery(VATS) with Reteplase fibrinolytic injection in the pleural space through chest tube in children with empyema 2021-04-08 anticipated 60 Complete https://irct.ir/trial/53443 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization of patients is done using "Random Allocation Software: RAS". In the mentioned software, the total number of sample sizes along with the number of groups of subjects are entered into the software. The software output includes a list that randomly distributes all patients in two groups. According to the time of referral, patients are distributed in two groups according to the mentioned list so that the sample size reaches the required number in each group, Blinding description: The method of blinding is that the patients are treated by the researcher according to the randomization list, but the outcome of the treatment is checked by a pediatric surgeon who is unaware of the type of treatment. 3 empyema. Intervention 1: Intervention group 1: In this group, patients undergo thoracoscopic decoction surgery. Intervention 2: Intervention group 2: In this group, the fibrinolytic drug Retplase made by Osweh Pharmaceutical Company under the brand name Retelies containing 18 mg of Retplase at a dose of 0.1 mg / kg is injected through the chest tube into the pleural space with empyema. No - There is not a plan to make this available Justification or reason for not sharing IPD is The plan belongs to a government agency and cannot be shared.