IRCT20120817010617N6 IRCT 2021-01-13 Zahedan University of Medical Sciences Comparison effects and Complications of propofol and isoflurane anesthesia for open cholecystectomy Comparison effects and Complications of propofol and isoflurane anesthesia for open cholecystectomy 2021-01-20 anticipated 60 Complete https://irct.ir/trial/53387 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization of samples to each group will be done by random permuted blocks. according to the sample size, which is 60 people, the number of 6 blocks will be determined. And there will be an equal number of cards from each group in each block, the order in blocks will be in a random permutated method. Therefore, by performing each block, 10 patients will be selected(5 from each group), Blinding description: The patients are not aware of the kind of used anesthetic medication. 3 Gallstone disease. Intervention 1: First Intervention group, Isofluran group: Isofluran 1.5% 1.5MAC inhalation in Anesthesia time. Intervention 2: Second Intervention group, Propofol group: Intravenous propofol infusion 100 µg/Kg per minutes in anesthesia time. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information