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IRCT201010204976N1 IRCT 2011-02-09 vice chancellor for research, Mashhad University of medical sciences. Synbiotic in Atopic Dermatitis in children Effect of a new synbiotic mixture on atopic dermatitis in children 2007-02-02 anticipated 40 Complete https://irct.ir/trial/5337 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 0 (exploratory trials) Atopic Dermatitis. Intervention 1: Participants were randomly divided into two groups. Intervention: Patients in the probiotic group received synbiotic containing 1 billion Colony Forming Unit(CFU) of Protexin Restore: a mixture of Lactobacillus casei, Lactobacillus rhamnosus, Streptococcus thermophilus, Bifidobacterium breve, Lactobacillus acidophilus, Bifidobacterium infantis, Lactobacillus bulgaricus and Fructooligosaccharide (Protexin healthcare, Somerset, United Kingdom), in the form of freeze dried powder twice daily for 8 weeks. Intervention 2: CONTROL: The control group received placebo powder without probiotics which were matched for size, shape, and volume of contents and manufactured by the same company, twice daily for 8 weeks.
public
scientific Hamid Ahanchian
Ghaem hospital, Ahmad Abad blvd, Mashhad iran
mashhad Iran (Islamic Republic of) +98 51 1801 2522 ahanchianh@mums.ac.ir Mashhad University Medical Sciences Iran (Islamic Republic of) Inclusion: Aged from 3 months to 6 years Mild to severe Atopic dermatitis Exclusion: Prior exposure to probiotics Were currently taking a course of antibiotics, or had other major medical problems no limit 6 years Both L-20.8 infantile (acute)(chronic) Treatment - Drugs Treatment - Drugs Participants were randomly divided into two groups. Intervention: Patients in the probiotic group received synbiotic containing 1 billion Colony Forming Unit(CFU) of Protexin Restore: a mixture of Lactobacillus casei, Lactobacillus rhamnosus, Streptococcus thermophilus, Bifidobacterium breve, Lactobacillus acidophilus, Bifidobacterium infantis, Lactobacillus bulgaricus and Fructooligosaccharide (Protexin healthcare, Somerset, United Kingdom), in the form of freeze dried powder twice daily for 8 weeks. CONTROL: The control group received placebo powder without probiotics which were matched for size, shape, and volume of contents and manufactured by the same company, twice daily for 8 weeks Severity of Atopic Dermatitis. Timepoint: At the beginning of the study, 2 months after intervention. Method of measurement: SCORAD method. Cytokine profile(IL-4, INF- Gamma ). Timepoint: At the beginning of the study, 2 months after intervention. Method of measurement: ELISA on supernatant of Blood lymphocyte culture. vice chancellor for research, Mashhad University of medical sciences. Approved 2008-05-21 Mashhad University medical sciences etic comittee Ghoreishi bulding, Daneshgah street, Mashhad, Iran Mashhad Iran (Islamic Republic of)