IRCT20201225049829N1 IRCT 2021-01-10 Mazandaran University of Medical Sciences Effect of oral betahistin in reducing of nausea and vomiting after surgery Effect of oral betahistin in reducing of nausea and vomiting after laparoscopic cholecystectomy with general anesthesia 2019-10-22 anticipated 120 Complete https://irct.ir/trial/53228 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The sampling method is two-stage. In the first stage, with the available sampling method, 120 patients are assigned to the intervention and control groups using the blocking method. The random allocation process is done by block allocation method with random allocation software, Blinding description: This study is a double-blind and statistical expert, project physicians and patients are unaware of the placement of patients in treatment groups and the data collection form is completed by the project nurse who is unaware of the study groups. 3 Postoperative nausea and vomiting. Intervention 1: Intervention group: Betahistine 16 mg tablets (manufactured by Octovorco) orally, 3 hours before surgery. Intervention 2: Control group: An oral placebo (made by Sari School of Pharmacy, with starch composition and similar in size and shape to betahistine tablets) 3 hours before surgery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Due to the confidentiality of information