IRCT20201220049776N1 IRCT 2023-05-27 Tehran University of Medical Sciences Comparison of 3-weekly administration of continuous dose cisplatin with divided dose in head and neck carcinoma Complication assessment of concurrent chemoradiotherapy with 100 mg/m2 continuous dose vs 100 mg/m2 divided into three consecutive days in patients with head and neck squamous cell carcinoma , A Randomized clinical trial 2019-12-11 anticipated 60 Complete https://irct.ir/trial/53206 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Permuted block randomization 60 participants was planned by 15 random blocks of 4, each including two interventions and two controls via online system (http://sealedenvelope.com). In order to apply concealment, unique codes was produced by the online system. Physicians knew the codes and after enrollment the participants allocated group become visible to patients and physicians by the physician's secretory. 2-3 Condition 1: Malignant neoplasm of base of tongue. Condition 2: Malignant neoplasm of other and unspecified parts of tongue. Condition 3: Malignant neoplasm of oropharynx. Condition 4: Malignant neoplasm of nasopharynx. Condition 5: Malignant neoplasm of hypopharynx. Condition 6: Malignant neoplasm of pyriform sinus. Condition 7: Malignant neoplasm of larynx. Intervention 1: Intervention group:In this group, they received cisplatin every 21 days at a dose of 100 mg per cubic meter divided into three consecutive days. Chemotherapy courses were between 2 and 3 courses during the course of radiation therapy. Intervention 2: Control group: In this group, they received cisplatin every 21 days at a dose of 100 mg per cubic meter continuously in 24 hours. Chemotherapy courses were between 2 and 3 courses during the course. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information