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IRCT20180609040016N4 IRCT 2021-06-05 Shiraz University of Medical Sciences Evaluation the effect of Punica granatum L. ointment in burn wound Evaluation the effect of Punica granatum L. ointment in second degree burn wound healing 2021-05-15 anticipated 30 Complete https://irct.ir/trial/53198 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization is done according blocked randomization with two groups in each block, so 15 blocks are needed. The block's arrangement is according to Random number table. If the number came even, AB block is selected and if the odd number came, BA block is selected. The drugs are packaged by the pharmacist in two groups as A and B, Blinding description: Patients are explained about Punica granatum L. ointment and all patients are informed and their details are recorded in the prepared questionnaire, but according to the type of dressing use; Punica granatum L. or silver sulfadiazine are blind, the method, form and appearance of the dressing are the same in both groups and is performed by two trained and specific nurses who are related to the blind research project. The wounds evaluated by a specialist doctor who does not know the type of dressing and is blind like a investigator. 3 Evaluation the effectiveness of Punica granatum L. in second degree burn wound healing. Intervention 1: Intervention group: Hospitalized patients with second degree burn wound with an area of ​​5% or less, first irrigation with sterile normal saline and then dressing with the ointment of Punica granatum L. plant, made by Shiraz School of Pharmacy, as four grams per one percent of burn wound will be done. Ingredients included Dracaena cinnabri, Olive oil, Cerussa, Cinnamomum camphora, Punica granatum, Lithargyoum and Honey wax. Intervention 2: Control group: dressing with silver sulfadiazine ointment (standard medical treatment) manufactured by Sina Darou with the same method as the intervention group with four grams per one percent of burn wound. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.
public Rahimeh Akrami
Sadra Blvd.
Shiraz Iran (Islamic Republic of) 7198754361 +98 71 3622 4315 rahimeh.akrami@yahoo.com Shiraz University of Medical Sciences scientific Abdolkhalegh Keshavarzi
Amir almomenin hospital, Sadra Blvd
Shiraz Iran (Islamic Republic of) 7198754361 +98 71 3622 4315 Keshavarzg@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Patients between 18 and 60 years old Burn case area 5% or less than 5%Less than one day burn passed Burn sources: flame or hot liquids Body mass index more than 18 and less than 25 Patients with second degree burn wound 18 years 60 years Both Not having skin diseases and skin allergies to herbal medicines Not having hepatic, renal, respiratory or cardiovascular diseases Not having malignancy, immune deficiency, anemia, poisoning, Trauma, Diabetes mellitus, joint injury or involvement Not be pregnant T21.2 Burn of second degree of trunk Treatment - Drugs Treatment - Drugs Intervention group: Hospitalized patients with second degree burn wound with an area of ​​5% or less, first irrigation with sterile normal saline and then dressing with the ointment of Punica granatum L. plant, made by Shiraz School of Pharmacy, as four grams per one percent of burn wound will be done. Ingredients included Dracaena cinnabri, Olive oil, Cerussa, Cinnamomum camphora, Punica granatum, Lithargyoum and Honey wax. Control group: dressing with silver sulfadiazine ointment (standard medical treatment) manufactured by Sina Darou with the same method as the intervention group with four grams per one percent of burn wound Wound healing time. Timepoint: Daily once. Method of measurement: Inspection and Photographic stereology method. Wound infection control. Timepoint: Days 1,3,7,10,13,21. Method of measurement: Wound Culture. Shiraz University of Medical Sciences Approved 2019-09-15 Ethics committee of Shiraz University of Medical sciences Shiraz University of Medical sciences, Zand Ave. Shiraz Fars Iran (Islamic Republic of)