IRCT20151128025274N5 IRCT 2020-12-30 Ahvaz University of Medical Sciences The effects of rutin flavonoid on type 2 diabetes mellitus The effects of rutin flavonoid supplement on glycemic status, lipid profile, plasma atherogenic index, brain derived neurotropic factor (BDNF), some serum inflammatory biomarkers and oxidative stress in patients with type 2 diabetes mellitus 2021-01-20 anticipated 50 Complete https://irct.ir/trial/53180 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Based on inclusion criteria, 50 patients will randomly allocated to placebo (n = 25) or intervention (n = 25) groups. Block design based on the combined analysis and using packed envelopes is used for randomization. In fact, according to pattern and using two codes of A and B 6 groups with 4 blocks are selected. This work is repeated in 2 steps. At the end, two A and B codes are assigned to the 2 last patients and the randomization is completed (50 patients). (step1; AABB, BBAA, ABAB, BABA, ABBA, BABA, step2; AABB, BBAA, ABAB, BABA, ABBA, BABA and AB), Blinding description: The researchers and patients will not informed of the contents of the packets. A third person of health care does the coding. This person will not aware of the details of the research trial. 2 Type 2 diabetes mellitus. Intervention 1: Intervention group: Every day, one tablet of 1 g rutin (containing 500 mg of pure rutin and 500 mg other compounds include di-calcium phosphate, microcrystalline cellulose, plant cellulose, stearic acid, magnesium stearic, silica, glycerin), made by the Solgar company, USA, after meals for 90 days. Intervention 2: Control group: One tablet of 1 g placebo/day (containing compound similar to supplement except rutin), made by the Faculty of Pharmacy of Ahvaz Jundishapur University of Medical Sciences, in terms of shape, color, size similar to supplement, after meals for 90 days. No - There is not a plan to make this available Justification or reason for not sharing IPD is The person's information will be confidential and the results will be as collective statistics