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IRCT20120307009229N6 IRCT 2022-02-14 Mashhad University of Medical Sciences Frequency of Oculocardiac Reflex in scleral buckling Comparison of the Effect of Intravenous Atropine and Hyoscine on the Frequency of Oculocardiac Reflex in Scleral Buckling Surgery: A double-blinded Randomized Controlled Clinical Trial 2019-05-15 anticipated 75 Complete https://irct.ir/trial/52862 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Other design features: none, Randomization description: In this study, a simple randomization method is used and each patient randomly removes a sealed envelope and announces the number inside it to the researcher, Blinding description: In this double-blinded clinical study, the drugs are injected by one person and each drug is prepared in a 2 cc syringe (2ml solution), the researcher who recorded the information and the patient did not know the type of drug prescribed. 3 Hypotony of eye and scleral buckling surgery. Intervention 1: first Intervention group- Hyoscine n-butyl bromide is injected in 20 mg and 2 ml of tolidaru before induction of anesthesia. Intervention 2: second Intervention group: Atropine sulfate is injected 0.02 mg/kg up to 0.5 mg in two ml made by Caspian before induction of anesthesia. Intervention 3: Control group- Distilled water is injected in two ml before induction of anesthesia. Yes - There is a plan to make this available What will be shared: Demographic characteristics of patients such as age, sex and weight, as well as changes in heart rate and blood pressure during scleral buckling surgery in patients are evaluated and compared with each other. When: After 2022 and the publication of articles in scientific journals To whom: medical students and professors and journal editors Conditions: except of patient nominal information, patient profiles such as age, sex, weight, and intraoperative hemodynamic changes such as heart rate and blood pressure are available, and individuals are allowed to perform any evaluation and analysis. Where to obtain: To access the study information in the following ways, people can apply and contact to Mehryar Taghavi Gilani tel: 0513858878 taghavim@mums.ac.ir Address: Mashhad Imam Reza Hospital - Anesthesia Ward How to obtain: Contact Mehryar Taghavi Gilani for any information about the type and method of study and statistical results, as well as the Data obtained. Phone 0513858878 Comments:
public mehryar taghavi gilani
bahar str
mashhad Iran (Islamic Republic of) 9184532435 +98 51 3858 3878 taghavim@mums.ac.ir Mashhad University of Medical Sciences scientific mehryar taghavi gilani
bahar str
mashhad Iran (Islamic Republic of) 9184532435 +98 51 3858 3878 taghavim@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) American Society of Anesthesiologists (ASA) class I and II 5 years no limit Both ASA > II, uncontrolled hypertension, coronary artery disease, respiratory disease, addiction, preoperative beta-blocker use, hypersensitivity to hyoscine and atropine H44.4 Hypotony of eye Prevention Prevention Placebo first Intervention group- Hyoscine n-butyl bromide is injected in 20 mg and 2 ml of tolidaru before induction of anesthesia. second Intervention group: Atropine sulfate is injected 0.02 mg/kg up to 0.5 mg in two ml made by Caspian before induction of anesthesia. Control group- Distilled water is injected in two ml before induction of anesthesia Oculocardiac reflex. Timepoint: before induction, after induction, and implantation of the endotracheal tube, at the beginning of surgery and every 10 minutes until the end of the operation. Method of measurement: heart rate changes. Blood pressure. Timepoint: before induction, after induction, and implantation of the endotracheal tube, at the beginning of surgery and every 10 minutes until the end of the operation. Method of measurement: intraoperative monitoring. Mashhad University of Medical Sciences Approved 2019-05-15 Ethics Committee of Mashhad University of Medical Science bahar str mashhad Razavi Khorasan Iran (Islamic Republic of)