IRCT20201117049418N1 IRCT 2020-11-20 Tehran University of Medical Sciences Effect of dexamethasone on tooth extraction Effect of local dexamethasone on pain, swelling and trismus after impacted third molar extraction 2012-02-05 anticipated 72 Complete https://irct.ir/trial/52349 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: simple individual randomization with sealed envelops that patient choose the envelope, there were 72 sealed envelopes that each one included group number and patient choose between envelopes and then he/she was included in one group, Blinding description: triple-blind randomized clinical trial study (surgeon, examiner, and statistical analyst All surgeries were performed by a skilled surgeon without any knowledge of the type of drug intervention. Drug intervention was done by a dentist who was informed about the plan and she was not involved in other steps of the study. 3 third molar extraction. Intervention 1: Intervention group: Group 1 received dexamethasone powder 4 mg inside the alveolar socket after washing and before flap suturing. Intervention 2: Intervention group: group 2 received dexamethasone 4 mg/ml in the masseter muscle through the oral mucosa before surgery and after anasthesia. Intervention 3: Intervention group: group 3 received ibuprofen 400 mg tablets one hour before surgery and every 6 hours for one day. Intervention 4: Control group: Control group: A hard gelatin capsule contains starch powder 1gr, was considered as a placebo which consumed orally one hour before surgery (group 4). Yes - There is a plan to make this available What will be shared: whole data are available When: from now till 2 years To whom: researcher Conditions: N/A Where to obtain: Farshadkhosraviani@gmail.com How to obtain: proposal and aim of their request Comments: