IRCT20190415043279N8 IRCT 2020-12-11 Sanandaj University of Medical Sciences The effect of periarticular dextrose prolotherapy and ozone on knee osteoarthritis The effect of combination of periarticular dextrose prolotherapy and ozone, on pain reduction in patients suffering from knee osteoarthritis 2020-03-20 anticipated 28 Complete https://irct.ir/trial/52311 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The placement of individuals will be in each of the intervention (injection in one of the right or left knee) and control (no injection in the opposite knee) groups. In the form of random quadruple blocks B, B, A, A are assigned to two random groups. Group A patients (injection around the right knee) and group B patients (injection around the left knee). The selection of the samples will be as the following arrangement: ABBA BBAA BABA AABB BAAB BAAB AABB ABAB AABB BAAB BAAB ABBA ABAB, Blinding description: This study is a single-blind randomized clinical trial. In fact, there is no separate control group in this study and each person will be in control of himself. For each person, the injection is given in only one knee and the other knee as a control. Participants are not blind to the intervention because the injection is given in one of the person's knees but colleagues who evaluate the outcome of the study are blind to the study. 3 knee arthritis. Intervention 1: Intervention group: Injection into one of the joints, The amount of injection is 8 ml of 5% dextrose and 2 ml of 1% lidocaine and 5 ml of ozone. Three injections are given at weekly intervals for each patient. Intervention 2: Control group: No injection in the opposite knee. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more information