<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT201102234877N3</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2011-09-04</date_registration>
      <primary_sponsor>Vice chancellor for research, Isfahan University of Medical Sciences</primary_sponsor>
      <public_title>comparison of efficacy of tooth brushing with three different dentifrices and wthout dentifrice in plaque removal.</public_title>
      <acronym></acronym>
      <scientific_title>comparative evaluation of plaque control fallowing tooth brushing with three different dentifrices and wthout dentifrice</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2010-10-23</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>30</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/5216</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Crossover, Purpose: Prevention.</study_design>
      <phase>N/A</phase>
      <hc_freetext>dental plaque.</hc_freetext>
      <i_freetext>Intervention 1: In the third session, the first step is type 3; ORIGINAL SENSODINE to all of the volenteers and ask them to brush with the new toothbrush and toothpaste for a week in orther to be familiar to them. Then ask them not to use any kind of plaque control method for 48 hours. The next step is mesuring of plaque and then ask them to brush with their new tooth brush and tooth paste for 2 minutes.In the next step, examiner mesures the post brushing plaque and amount of plaque reduction and record it. Intervention 2: The last session is asking volenteers not to use any kind of plaque control method for 48 hours. Then mesuring of plaque and then ask them to brush with their new tooth brush and without any toothpaste for 2 minutes.In the next step, examiner mesures the post brushing plaque and amount of plaque reduction and record it. Intervention 3: The first step is giving the same toothbrush (gum 411) and toothpaste type 1; WHITENING POONE to all of the volenteers and ask them to brush with the new toothbrush and toothpaste for a week in orther to be familiar to them. Then ask them not to use any kind of plaque control method for 48 hours. The next step is mesuring of plaque and then ask them to brush with their new tooth brush and tooth paste for 2 minutes.In the next step, examiner mesures the post brushing plaque and amount of plaque reduction and record it. Intervention 4: In the next session, first step is giving the toothpaste type2; 3DWHITE CREST to all of the volenteers and ask them to brush with the new toothbrush and toothpaste for a week in orther to be familiar to them. Then ask them not to use any kind of plaque control method for 48 hours. The next step is mesuring of plaque and then ask them to brush with their new tooth brush and tooth paste for 2 minutes.In the next step, examiner mesures the post brushing plaque and amount of plaque reduction and record it.</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan></results_IPD_plan>
      <results_IPD_description></results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Dr Jaber Yaghini</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Periodontology department, Dental faculty,Isfahan University of Medical Sciences</address>
        <city>Isfahan</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>81746-73461</zip>
        <telephone>+98 31 1434 2136</telephone>
        <email>j_yaghini@dnt.mui.ac.ir</email>
        <affiliation>Isfahan University of Medical Sciences</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Dr Jaber Yaghini</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Periodontology department-Dental faculty-Isfahan medical university-Hezar jerib avenue-</address>
        <city>Isfahan</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>81746-73461</zip>
        <telephone>+98 31 1434 2136</telephone>
        <email>j_yaghini@dnt.mui.ac.ir</email>
        <affiliation>Isfahan University of Medical Sciences</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Iran (Islamic Republic of)</country2>
    </countries>
    <criteria>
      <inclusion_criteria>Inclusion criteria:&#13;
age&gt;18 years and at least 5 evaluable teeth per quadrant;&#13;
Exclusion criteria:&#13;
orthodontic appliances;&#13;
removable denture;&#13;
pregnancy;&#13;
smoking;&#13;
periodontitis;&#13;
any systemic disease that may effect the oral condition;&#13;
hypersensitivity to the components of the dentifrices;</inclusion_criteria>
      <agemin>no limit</agemin>
      <agemax>no limit</agemax>
      <gender>Both</gender>
      <exclusion_criteria></exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code>K03.6</hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword>Deposits [accretions] on teeth</hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Prevention</i_code>
      <i_code>Prevention</i_code>
      <i_code>Prevention</i_code>
      <i_code>Prevention</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>In the third session, the first step is type 3; ORIGINAL SENSODINE to all of the volenteers and ask them to brush with the new toothbrush and toothpaste for a week in orther to be familiar to them. Then ask them not to use any kind of plaque control method for 48 hours. The next step is mesuring of plaque and then ask them to brush with their new tooth brush and tooth paste for 2 minutes.In the next step, examiner mesures the post brushing plaque and amount of plaque reduction and record it.</i_keyword>
      <i_keyword>The last session is asking volenteers not to use any kind of plaque control method for 48 hours. Then mesuring of plaque and then ask them to brush with their new tooth brush and without any toothpaste for 2 minutes.In the next step, examiner mesures the post brushing plaque and amount of plaque reduction and record it.</i_keyword>
      <i_keyword>The first step is giving the same toothbrush (gum 411) and toothpaste type 1; WHITENING POONE to all of the volenteers and ask them to brush with the new toothbrush and toothpaste for a week in orther to be familiar to them. Then ask them not to use any kind of plaque control method for 48 hours. The next step is mesuring of plaque and then ask them to brush with their new tooth brush and tooth paste for 2 minutes.In the next step, examiner mesures the post brushing plaque and amount of plaque reduction and record it.</i_keyword>
      <i_keyword>In the next session, first step is giving the toothpaste type2; 3DWHITE CREST to all of the volenteers and ask them to brush with the new toothbrush and toothpaste for a week in orther to be familiar to them. Then ask them not to use any kind of plaque control method for 48 hours. The next step is mesuring of plaque and then ask them to brush with their new tooth brush and tooth paste for 2 minutes.In the next step, examiner mesures the post brushing plaque and amount of plaque reduction and record it.</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>Dental plaque. Timepoint: Before brushing and after brushing. Method of measurement: Disclosing tab.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome></sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>Vice chancellor for research, Isfahan University of Medical Sciences</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2010-09-23</approval_date>
        <contact_name>Isfahan medical university</contact_name>
        <contact_address>Periodontology department-Dental faculty-Isfahan medical university-Hezar jerib avenue- Isfahan  Iran (Islamic Republic of)</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
