]>
IRCT20111121008146N33 IRCT 2020-11-18 Shahid Beheshti University of Medical Sciences Investigating the effects of intravenous laser therapy on the recovery process in patients with Acute Kidney Injury (AKI) using urinary NGAL Investigating the effects of intravenous laser therapy on the recovery process in patients with Acute Kidney Injury (AKI) using urinary NGAL 2018-08-23 anticipated 40 Complete https://irct.ir/trial/52053 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be divided into case and control groups based on randomly generated numbers. Group assignments will be concealed in sequentially numbered dark envelopes. The envelopes will be opened after the preliminary patient evaluation by a physician. Neither the patients nor the clinical evaluator will be aware of the group assignments, Blinding description: Patient assessments will be performed before and after the treatments by a competent physician who is not affiliated with the research plan and is unaware of the treatment groups. Patients are not informed about the treatment groups. N/A Acute kidney injury. Intervention 1: Control group: 7 sessions of sham laser treatment. Intervention 2: Intravenous laser treatment with red or infrared radiation (wavelength=600-1100 nm, power=2 mW, irradiation time=30 minutes) will be performed in seven sessions, every other day. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no need to publish. A summary will be provided in the results section of the article.
public Sheida Malekian
Shohadaye Tajrish Hospital, Tajrish, Tehran
Tehran Iran (Islamic Republic of) 1989934148 +98 21 2274 9221 laser.cntr@yahoo.com Shahid Beheshti University of Medical Sciences scientific Mohammadreza Razzaghi
Shohadaye Tajrish Hospital, Tajrish, Tehran
Tehran Iran (Islamic Republic of) 1989934148 +98 21 2274 9221 laser.cntr@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Patients with intra-renal acute kidney injury (AKI) due to ATN (including toxic and ischemic interstitial nephritis) no limit no limit Both Patients with pre-renal and post-renal acute kidney failure Patients with glomerulonephritis Patients who need immunosuppressive drugs such as patients with Lupus Patients who had been taking Omega-3 and corticosteroids within the past month Pregnant patients Patients with photosensitivity Patients with malignancy N17 Acute kidney failure Placebo Treatment - Other Control group: 7 sessions of sham laser treatment Intravenous laser treatment with red or infrared radiation (wavelength=600-1100 nm, power=2 mW, irradiation time=30 minutes) will be performed in seven sessions, every other day. Urine Neutrophil gelatinase-associated lipocalin (NGAL). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Measuring the NGAL levels in urine samples. Glomerular filtration rate (GFR). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Using the following equation: (140-age)×(weight)× (0.85 if female)/72×Cr. 24-hour urine output. Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Urine sample. Blood urea nitrogen (BUN). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Blood sample. Creatinine. Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Blood sample. Patient's quality of life (mental and physical health). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: 36-Item Short Form Survey. Biochemical profile (Calcium, Phosphor, potassium, and sodium levels in blood, complete blood count, fasting blood sugar, total glycerides, total cholesterol, LDL, HDL, AST, ALT, ALKP). Timepoint: Before the treatment and after the last session of laser therapy. Method of measurement: Patient's blood sample. Shahid Beheshti University of Medical Sciences Approved 2017-12-10 Shahid Beheshti University Ethics Committee in Biomedical Research Shahid Beheshti University of medical sciences, Daneshjoo Blv, Velenjak Tehran Tehran Iran (Islamic Republic of)