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IRCT20200825048515N11 IRCT 2020-11-09 Esfahan University of Medical Sciences The prophylactic effect of neostigmine and atropin combination on the occurrence of post-dural puncture headache in patients undergoing spinal anesthesia Comparative study of the prophylactic effect of neostigmine and atropin combination on the occurrence of post-dural puncture headache in patients undergoing spinal anesthesia with control group 2020-11-21 anticipated 100 Complete https://irct.ir/trial/52041 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: In this study, the drug combination of "neostigmine and atropine" and normal saline were prepared by the operating room nurse in the same volume and marked with labels A and B. It is then given daily to the researcher and will be administered accidentally for patients. Therefore, the patient and the researcher will not have any information about the two prescribed drugs. 3 Lower limb surgery. Intervention 1: Control group: Patients in this group will be subjected to the spinal block as usual. After confirmation of anesthesia, normal saline is administered intravenously per 10 kg of patient weight. Intervention 2: Intervention group: Patients in this group will be subjected to the spinal block as usual. After confirmation of the anesthesia, a combination of 400 g of neostigmine and 200 g of pre-prepared atropine is administered intravenously for every 10 kg of patient weight. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Mohammad Golparvar
Anesthesiology Department, Kashani Hospital, Kashani Street.
Isfahan Iran (Islamic Republic of) 8183983434 +98 31 3233 0091 z.ahmadzade@gmail.com Esfahan University of Medical Sciences scientific Mohammad Golparvar
Anesthesiology Department, Kashani Hospital, Kashani Street.
Isfahan Iran (Islamic Republic of) 8183983434 +98 31 3233 0091 z.ahmadzade@gmail.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Patient consent to participate in the study American Anesthesiologists Association Classification I and II Duration of surgery less than 2 hours 15 years 65 years Both Taking anticoagulants Existence of a nerve lesion in the limb/spine Coagulation diseases History of spinal surgery, spinal canal stenosis Conductive disorders of the heart History of migraine headaches Opioid addiction History of malignancy S89.92XA Unspecified injury of left lower leg, initial encounter Placebo Treatment - Drugs Control group: Patients in this group will be subjected to the spinal block as usual. After confirmation of anesthesia, normal saline is administered intravenously per 10 kg of patient weight. Intervention group: Patients in this group will be subjected to the spinal block as usual. After confirmation of the anesthesia, a combination of 400 g of neostigmine and 200 g of pre-prepared atropine is administered intravenously for every 10 kg of patient weight. Pain severity. Timepoint: From first day to seven days after surgery. Method of measurement: Visual Analogue Scale (VAS). Duration of headache. Timepoint: From first day to seven days after surgery. Method of measurement: Counting the number of days suffering from headache. Isfahan University of Medical Sciences Approved 2020-06-28 Ethics committee of Isfahan University of Medical Sciences Hezar Jarib Ave, Azadi Square. Isfaha Isfehan Iran (Islamic Republic of)