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IRCT20200809048341N2 IRCT 2020-12-10 Yazd University of Medical Sciences Effect of Epinephrine in treatment of hypotension of intubation Effect of push dose Epinephrine on mortality rate following intubation in hypotensive patients 2020-12-21 anticipated 60 Complete https://irct.ir/trial/52003 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 mortality following intubation in hypotensive patients. Intervention 1: Intervention group: For 30 patients who have SBP less than 90 mm of mercury or MAP less than 65 mm of mercury in 30 minutes before to 1 hour after intubation, a push dose of Epinephrine at a concentration of 1/100000 at 1cc every 2 minutes will be injected to the peripheral vessel until SBP become above 90 or MAP become above 65 mm of mercury. In addition, patients' blood pressure will be checked manually with a Mercury sphygmomanometer. Vital signs are measured and recorded 30 minutes before intubation and then every 15 minutes to 1 hour after intubation and at the end of 24 hours. If the side effects of Epinephrine happened, the administration will be discontinued. Intervention 2: Control group: The control group will be selected from 30 patients who underwent intubation in the emergency department of Yazd Shahid Sadoughi or Shahid Rahnemoun Hospital one year before the start of the study and met the inclusion and exclusion criteria. If these patients have a defective record, they will be removed from the study. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Fatemeh Sadat Mohammadi Hanzaie
Dead End 22, Naeem Abad St., Kashani St.
Yazd Iran (Islamic Republic of) 8916768759 +98 35 3824 9596 frozenfsm@gmail.com Yazd University of Medical Sciences scientific Soheila Azimi Aabarghouei
Emergency ward, Shahid Sadoughi Hospital, Ebne sina Blvd.
Yazd Iran (Islamic Republic of) 8913893111 +98 35 3828 2682 S.azimi@ssu.ac.ir Yazd University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) systolic blood pressure lesser than 90 mmHg or mean arterial pressure lesser than 65 mmHg 14 years 65 years Both pregnancy heart rate more than 180 beat per minute T88.4XXA Failed or difficult intubation, initial encounter Treatment - Drugs Treatment - Drugs Intervention group: For 30 patients who have SBP less than 90 mm of mercury or MAP less than 65 mm of mercury in 30 minutes before to 1 hour after intubation, a push dose of Epinephrine at a concentration of 1/100000 at 1cc every 2 minutes will be injected to the peripheral vessel until SBP become above 90 or MAP become above 65 mm of mercury. In addition, patients' blood pressure will be checked manually with a Mercury sphygmomanometer. Vital signs are measured and recorded 30 minutes before intubation and then every 15 minutes to 1 hour after intubation and at the end of 24 hours. If the side effects of Epinephrine happened, the administration will be discontinued. Control group: The control group will be selected from 30 patients who underwent intubation in the emergency department of Yazd Shahid Sadoughi or Shahid Rahnemoun Hospital one year before the start of the study and met the inclusion and exclusion criteria. If these patients have a defective record, they will be removed from the study. Percentage of people whose systolic blood pressure reaches above 90 mm of mercury or mean arterial pressure reaches above 65 mm of mercury after epinephrine administration. Timepoint: 30 minutes before until 1 hour after intubation when the patient has a systolic blood pressure less than 90 mm of mercury or a mean arterial pressure less than 65 mm of mercury. Method of measurement: Mercury sphygmomanometer. Yazd University of Medical Sciences Approved 2019-08-27 Research ethics committee of school of medicine _ shahid sadoughi university of medical sciences Central building of Shahid Sadoughi university of medical sciences, Bahonar square, Yazd Yazd Yazd Iran (Islamic Republic of)