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IRCT20201031049208N1 IRCT 2020-11-08 Ahvaz University of Medical Sciences Compression the efficacy of Topiramate and Propranolol in patients with migraine Compression the efficacy of Topiramate and Propranolol in patients with migraine with Aura 2020-09-22 anticipated 32 Complete https://irct.ir/trial/51998 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Individuals are randomly divided into two groups based on simple randomization method using random digits table. In this method, a collection of non-template numbers is randomly generated and arranged as a table. Even numbers for the intervention group (1) and the odd numbers for the intervention group (2) are considered. According to the number of patients, they are randomly assigned to one of the intervention groups, Blinding description: Participants are informed about the purpose and method of study. After receiving informed consent, they are blinded to the study groups to unify patients in terms of their empathy sense. Researchers responsible for data collection and analyses will also blinded to the groups allocation for preventing personal viewpoint. 2 Migraine. Intervention 1: Intervention group (1): Topiramate will be started at a daily dose of 25 mg and increased to 100 mg daily, depending on patient tolerance. The duration of taking the drug is three months. Intervention 2: Intervention group (2): Propranolol at a dose of 20 mg is prescribed twice a day for three months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.
public Saba Farashi
Golestan Hospital, Farvardin Ave.
Ahvaz Iran (Islamic Republic of) 6135715794 009861329235893 Farashi86.sf@gmail.com Ahvaz University of Medical Sciences scientific Seyed Ehsan Mohammadiani Nejad
Golestan Hospital, Farvardin Ave.
Ahvaz Iran (Islamic Republic of) 6135715794 009861322235292 Ehsanneuro@gmail.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) Age group 18 to 65 years History of migraine with Aura (according to the definition of the international classification of headache disorders) Patients with the frequency of migraine attacks at least once a week 18 years 65 years Both Systolic blood pressure below 90 mmHg Heart rate below 65 beats per minute Incidence of tension-type headache attacks in the last month Previous history of analgesia or migraine specific medication History of known allergy to Topiramate or Propranolol History of kidney stone History of depression G43 Migraine Treatment - Drugs Treatment - Drugs Intervention group (1): Topiramate will be started at a daily dose of 25 mg and increased to 100 mg daily, depending on patient tolerance. The duration of taking the drug is three months. Intervention group (2): Propranolol at a dose of 20 mg is prescribed twice a day for three months. Assessing the degree of disability. Timepoint: Before and after 3 months of taking the drug. Method of measurement: Migraine Disability Assessment (MIDAS) scale questionnaire. Ahvaz University of Medical Sciences Approved 2020-02-22 Ethics committee of Ahvaz University of Medical Sciences Research deputy, Ahvaz Jundishapur University Of Medical Sciences, Golestan Blvd. Ahvaz Khouzestan Iran (Islamic Republic of)