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IRCT20160430027677N20 IRCT 2020-11-02 Oroumia University of Medical Sciences Evaluation the effect of clonidine and dexmedetomidine administration on bleeding during surgery The effect of oral clonidine and intravenous dexmedetomidine administration on bleeding during functional endoscopic sinus surgery 2019-05-22 anticipated 64 Complete https://irct.ir/trial/51930 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients will be randomly assigned into three groups of Dexmedetomidine (group D)and Clonidine (group C) and placebo (group P) using Random Allocation Software 2.0, and the target codes will be written and placed in sealed envelopes with sequential allocation using double-blind method, Blinding description: The anesthesiologist will be unaware of which patient will be assigned to which group. Oral clonidine drug and dexmedetomidine syringes will be identical and only the operating room and ward nurse will knew about the contents of each of them, and finally, after collecting information from the anesthesia residents, the anesthesiologist will be informed of the group each patient will be assigned to. 2-3 bleeding. Intervention 1: Intervention group: patients will receive Clonidine 200 mcg oral tablet, 90 minutes before surgery. Intervention 2: Intervention group: Patients in Group dexmedetomidine will be received 0.4 mcg/kg/h. Intervention 3: Control group: will be received oral placebo 90 minutes before surgery and saline Infusion during surgery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Shahryar Sane
Orjanse alley, Resalat blvd
Urmia Iran (Islamic Republic of) 5714783734 +98 44 3223 4897 sanesh@umsu.ac.ir Oroumia University of Medical Sciences scientific Shahryar Sane
Orjanse alley, Resalat blvd
Urmia Iran (Islamic Republic of) 5714783734 +98 44 3223 4897 sanesh@umsu.ac.ir Oroumia University of Medical Sciences Iran (Islamic Republic of) Aged 20-60 years old American Society of Anesthesiologists physical status classification I,II General anesthesia 20 years 60 years Both Patients with diabetes mellitus Coagulation problems Liver or kidney failure Cerebrovascular disease High blood pressure Asthma Chronic obstructive pulmonary disease Severe end organ damage Psychosis Patients receiving antipsychotic medication Hypersensitivity to dexmedetomidine and clonidine Drug abusers Use of beta blockers drugs Heart rate less than 55 beats per minute Prevention Prevention Placebo Intervention group: patients will receive Clonidine 200 mcg oral tablet, 90 minutes before surgery. Intervention group: Patients in Group dexmedetomidine will be received 0.4 mcg/kg/h Control group: will be received oral placebo 90 minutes before surgery and saline Infusion during surgery. Amount of bleeding. Timepoint: during surgery. Method of measurement: Measuring the amount of blood inside the suction device and the gases used. Quality of the surgical field. Timepoint: During surgery. Method of measurement: Boezaart scale. Mean arterial pressure. Timepoint: Every 5 minutes during the surgery. Method of measurement: Non invasive pressure gauge. Mean pulse Rate. Timepoint: Every 5 minutes during the surgery. Method of measurement: Electrocardiogram. Umia University of Medical Sciences Approved 2019-05-15 Ethics commitee of Urmia University of Medical Sciences Emergent Street, Ershad Avenue Urmia West Azarbaijan Iran (Islamic Republic of)