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IRCT20170408033280N3 IRCT 2020-12-12 Oroumia University of Medical Sciences The effect of intravenous Propofol, Dexamethasone and Ondansetron in preventing nausea and vomiting after cesarean section Comparison of the prophylactic effect of intravenous Propofol, Dexamethasone and Ondansetron on post operative nausea and vomiting in elective cesarean section under spinal anesthesia 2019-07-23 anticipated 120 Complete https://irct.ir/trial/51837 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients were randomly divided into intervention and control groups using Random allocation computer software.By selecting the simple randomization method in the randomization box and entering the determined total sample size in this software, numbers were given to the patients and the patients allocated into four groups according computer generated numbers, Blinding description: This study was a double-blind clinical trial. participants and researcher were unaware about the patient belonged to the interventions or a control groups. The drugs were injected by an anesthesiologist (other than the lead researcher) who was unaware of the content of the study. 3 Nausea and vomiting after cesarean section. Intervention 1: Intervention group: group 1: Received 0.05 Mg/kg of Ondansetron from Kaspian-Farma company ( Iran country) after the fetus leaves and umbilical cord clamp by the surgeon. Intervention 2: Intervention group: group 2: Received 0.1 Mg/kg of Dexamethasone from Shimi-Daru company ( Iran country) after the fetus leaves and umbilical cord clamp by the surgeon. Intervention 3: Intervention group: group 3: Received 0.2 Mg/kg of Propofol from Tehran-Shimi company (Iran country) after the fetus leaves and umbilical cord clamp by the surgeon. Intervention 4: Control group: Normal saline. Yes - There is a plan to make this available What will be shared: The results of the study will be published as an article. When: After publishing the article To whom: Researchers Conditions: As published article Where to obtain: Corresponding author How to obtain: by email address Comments:
public Dr. Ebrahim Hassani
Shahid Motahhari Hospital; Kashani street; Urmia; Iran.
Urmia Iran (Islamic Republic of) 5714783734 +98 44 3198 8293 ehassani@umsu.ac.ir Oroumia University of Medical Sciences scientific Dr. Ebrahim Hassani
Shahi Motahhari Hospital; Kashani street; Urmia; Iran.
Urmia Iran (Islamic Republic of) 5714783734 +98 44 3198 8293 ehassani@umsu.ac.ir Oroumia University of Medical Sciences Iran (Islamic Republic of) Pregnant women under cesarean section Age group 15-35 years old American Society of Anesthesiologists classification system I and II (ASA II and ASA II) 15 years 35 years Female Having a history of anti depression drugs consumption Gastrointestinal disorders Motion sickness Weight >100 Kg Having a history of other surgeries Patients with preeclampsia and eclampsia during pregnancy Taking anti-nausea and vomiting medications 24 hours before cesarean section R11 Nausea and vomiting Treatment - Drugs Treatment - Drugs Treatment - Drugs Placebo Intervention group: group 1: Received 0.05 Mg/kg of Ondansetron from Kaspian-Farma company ( Iran country) after the fetus leaves and umbilical cord clamp by the surgeon. Intervention group: group 2: Received 0.1 Mg/kg of Dexamethasone from Shimi-Daru company ( Iran country) after the fetus leaves and umbilical cord clamp by the surgeon. Intervention group: group 3: Received 0.2 Mg/kg of Propofol from Tehran-Shimi company (Iran country) after the fetus leaves and umbilical cord clamp by the surgeon. Control group: Normal saline Nausea. Timepoint: Recovery and six hours after surgery. Method of measurement: Asking the patient. Vomoting. Timepoint: Recovery and six hours after surgery. Method of measurement: Push out stomach contents from the mouth. Oroumia University of Medical Sciences Approved 2019-06-19 Ethics Committee of Urmia University of Medical Sciences Urmia University of Medical Sciences, Resalat Street, Jahad Ave, Urmia, Iran. Urmia West Azarbaijan Iran (Islamic Republic of)