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IRCT20201016049048N1 IRCT 2020-11-04 Shiraz University of Medical Sciences Effect of Iranian Borage on the management of Covid-19 symptoms Evaluation of the effectiveness of Iranian Borage Aerial Part infusion on the management of Covid-19 mild to moderate symptoms: a clinical trial 2020-11-07 anticipated 60 Complete https://irct.ir/trial/51767 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The randomization method will be blocked randomization (Quaternary random blocks). Randomization units are individuals. Sixty patients are randomly assigned to one of the two intervention and control groups using Random Allocation Software. This study is a double-blind method and patients in the intervention group will receive the intervention drug in addition to the routine treatment, but in the control group, they will receive the placebo in addition to the routine treatment, Blinding description: The study will be a double-blind trial and only the evaluator knows the results and the code of the intervention or control group. The containers of the drug and placebo are quite similar in appearance. The intervention and control groups will be separated by receiving a code. 0 (exploratory trials) corona virus (covid-19). Intervention 1: Intervention group: Patients in the intervention group will receive Iranian Borage Aerial Part infusion (1 g/100 cc water) TID for 5 days in addition to the routine treatment. Intervention 2: Control group: Patients in the control group will receive the placebo (100 cc boiled water) TID for 5 days in addition to the routine treatment. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Mohammad mehdi Zarshenas
Shiraz school of pharmacy, Karafrin Street
Shiraz Iran (Islamic Republic of) 7146864685 +98 71 3242 4127 zarm@sums.ac.ir Shiraz University of Medical Sciences scientific Mohammad mehdi Zarshenas
Shiraz school of pharmacy, Karafrin Street
Shiraz Iran (Islamic Republic of) 7146864685 +98 71 3242 4127 zarm@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Patients with COVID-19 confirmed by RT-PCR and Ground glass view on CT scan Patients with COVID-19 symptoms (such as fever, muscle pain, chest discomfort, cough, reduced CBC and platelets, increased CRP and ESR) who have been exposed to suspected people in the last 14 days Having a conscious consent form signed to participate in the study Not participating in similar studies at the same time 18 years no limit Both People with a history of allergy to herbal medicines Having liver, kidney and cardiovascular diseases Permanent use of psychiatric drugs Pregnant and breastfeeding women People who can't swallow Having endocrine diseases like diabetes U07.1 COVID-19, virus identified Treatment - Drugs Placebo Intervention group: Patients in the intervention group will receive Iranian Borage Aerial Part infusion (1 g/100 cc water) TID for 5 days in addition to the routine treatment. Control group: Patients in the control group will receive the placebo (100 cc boiled water) TID for 5 days in addition to the routine treatment. Fever. Timepoint: At the beginning and end of the study. Method of measurement: Digital thermometer. Respiratory status. Timepoint: At the beginning and end of the study. Method of measurement: Observation. White blood cell count. Timepoint: At the beginning and end of the study. Method of measurement: Blood sample test. Platelet blood count. Timepoint: At the beginning and end of the study. Method of measurement: Blood sample test. Erythrocyte Sedimentation Rate. Timepoint: At the beginning and end of the study. Method of measurement: Blood sample test. C-reactive protein. Timepoint: At the beginning and end of the study. Method of measurement: Blood sample test. Vital capacity. Timepoint: At the beginning and end of the study. Method of measurement: Observation. Shiraz University of Medical Sciences Approved 2020-04-04 Ethics committee of Shiraz University of Medical Sciences Zand street Shiraz Fars Iran (Islamic Republic of)