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IRCT20181208041886N1 IRCT 2020-10-18 Esfahan University of Medical Sciences Levamizole in treatment of COVID19. لوامیزول Evaluation of levamizole on treatment of patients with COVID 19 infection: a controlled clinical trial study. 2020-10-22 anticipated 60 Complete https://irct.ir/trial/51501 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: nothing, Randomization description: The selected patients on inclusion and exclusion criteria will be randomized in two experimental and control groups in 15 randomized block. In every block 4 patients will be setelled (2 patient as control and 2 as interventional). At first the physician will visit the patients and on the clinical criteria he/she decided that the disease is mild, moderate and / or sever and the patient will setelled in the blocks and groups (control or interventional), Blinding description: In this study the patients and the physician who evaluate the signs and symptoms of the patients are blinded about the therapy. To prevent of the bias the levamizole tablet will be give the patients accompanied with other drugs. On the other hand the assessor also will not be informed about the drugs of the patients. N/A COVID19. Intervention 1: Intervention group: the patients with diagnosis of COVID19 with be treated by tablet Levamisole 50 mg daily for 14 days in addition to standard therapies for these patients. the sign and symptoms of the patients will be evaluated daily. Intervention 2: Control group: the patient with diagnosis of COVID19 will give the standard therapies and without Levamisole. Yes - There is a plan to make this available What will be shared: the article from this study will be distributed the effect of Levamisole on treatment of COVID 19 infection When: immediately after article publish To whom: Every body Conditions: no condition Where to obtain: published article How to obtain: No procedure Comments: No comment
public Morteza Pourahmad
Sofeh street
Isfahan Iran (Islamic Republic of) 8189111491 +98 31 3322 0996 mortezapourahmad@yahoo.com Esfahan University of Medical Sciences scientific Morteza Pourahmad
Sofe Street
Isfahan Iran (Islamic Republic of) 8189111491 +98 31 3322 0996 mortezapourahmad@yahoo.com Esfahan University of Medical Sciences Iran (Islamic Republic of) age =or > 18 years Diagnosis of COVID19 infection was made by positive test for RtPCR on nasopharyngeal swab, Lung HRCT and the opinion of infectious diseases specialist. informed consent of patient for study the possibility of patient follow up. 18 years no limit Both Another cause for signs and symptoms hypersensitivity to levamizole consumption of other antibiotics on the neck. Dyspnea Pregnancy breat feeding U07.1 U07.1 COVID-19, virus identified•U07.2 COVID-19, virus not identifiedoClinically-epidemiologically diagnosed COVID-19oProbable COVID-19 oSuspected COVID-19 Treatment - Drugs Treatment - Drugs Intervention group: the patients with diagnosis of COVID19 with be treated by tablet Levamisole 50 mg daily for 14 days in addition to standard therapies for these patients. the sign and symptoms of the patients will be evaluated daily. Control group: the patient with diagnosis of COVID19 will give the standard therapies and without Levamisole. Discontinuation of fever. Timepoint: Daily. Method of measurement: evaluation by a physician. Improvement of dyspnea. Timepoint: Daily. Method of measurement: evaluation by physician. Decreasing of cogh. Timepoint: Daily. Method of measurement: evaluation by physician. Elevation of O2sat of the blood. Timepoint: Daily. Method of measurement: evaluation by physician. Blood presure improvement. Timepoint: Daily. Method of measurement: evaluation by physician. Pulse rate improvement. Timepoint: Daily. Method of measurement: evaluation by physician. Improvement of the patient which has had COVOD-19>. Timepoint: 14 days. Method of measurement: evaluation of the patient by a physician. Research assistant of Isfahan University of Medical Sciences Approved 2020-06-22 Ethics committee of Isfahan University of Medical Sciences Sofeh Street Isfahan Isfehan Iran (Islamic Republic of)