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IRCT20181030041504N1 IRCT 2020-11-08 Sirjan Faculty of Medical Science Evaluation of the combined effect of Hesperidin,Artemisinin- Artemisia annua, Noscapine, N-acetylcysteine, Resveratrol supplements and high dose of vitamin C on treatment, clinical symptoms of non-hospitalization and hospitalization patients with symptomatic COVID-19 effect of Hesperidin,Artemisinin- Artemisia annua, Noscapine, N-acetylcysteine, Resveratrol supplements and high dose of vitamin C on treatment, clinical symptoms of non-hospitalization and hospitalization patients with symptomatic COVID-19 2020-10-07 anticipated 100 Complete https://irct.ir/trial/51482 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: For this purpose, we will use the quadruple block method (Block Randomization). Random allocation software will be used for this purpose. We prepare two sheets of paper. On a sheet we write the letter I meaning "Intervention" and on a sheet the letter S means "Standard treatment". Mix the sheets together and place them in the desk drawer. With the referral of each eligible patient, one of the leaflets will be randomly taken out and based on this extracted leaflet will be assigned to one of the two intervention groups. It should be noted that the pulled out sheets will not be returned to the drawer until all four sheets have been pulled out. After accidentally pulling out all four sheets, all the sheets are returned to the drawer and the above procedure will be continued for the next four patients until the desired sample size is reached, Blinding description: Participant, Evaluator, Data analyst, Data safety and Monitoring committee. 3 covid-19. Intervention 1: Intervention group: non-hospitalization patients with symptomatic COVID-19 received 1. Artemisia annua - Artemisinin ( Manufactured by Longlifenutri)150 mg every 24 hours 2. Dose of 1 g of vitamin C (Manufactured by Daroupakhsh) intravenous vitamin (2 ampoules of 500 mg in 250 cc of sodium chloride serum for 30 minutes) every 24 hours 3. Dose of 5 cc of noscapine ( Manufactured by Faran Shimi) each Eight hours 4. 500 mg dose of hesperidin (Manufactured by Swanson) every 24 hours 5. Resveratrol 500 mg (Manufactured by A Squard) every 24 hours 6. NAC 600 mg ( Manufactured by Osvah ) every 12 hours . The duration of treatment is estimated at ten days. Supplements are taken orally and vitamin C is given to patients as an injection. Intervention 2: Control group: non-hospitalization patients with symptomatic COVID-19 Protocol of the Ministry of Health. Intervention 3: Intervention group: hospitalization patients with symptomatic COVID-19 received 1. Artemisia annua - Artemisinin ( Manufactured by Longlifenutri)150 mg every 12hours 2. Dose of 1 g of vitamin C (Manufactured by Daroupakhsh) intravenous vitamin (2 ampoules of 500 mg in 250 cc of sodium chloride serum for 30 minutes) every 12 hours 3. Dose of 5 cc of noscapine ( Manufactured by Faran Shimi) each Eight hours 4. 500 mg dose of hesperidin (Manufactured by Swanson) every 24 hours 5. Resveratrol 500 mg (Manufactured by A Squard) every 24 hours 6. NAC 600 mg ( Manufactured by Osvah ) every 12 hours . The duration of treatment is estimated at ten days.Supplements are taken orally and vitamin C is given to patients as an injection. Intervention 4: Control group: hospitalization patients with symptomatic COVID-19 Protocol of the Ministry of Health. Yes - There is a plan to make this available What will be shared: Main outcome data, statistical analysis, final report, informed consent form When: 6 months after publish the results To whom: Academic researchers Conditions: Master of Medical Sciences PhD in Medical Sciences specialist Contribute to the advancement of science Where to obtain: Email m.mohamadpour2817@yahoo.com Contact number: 09120031782 Dr. Masoomeh Mohamadpour - Tehran How to obtain: 48-72 hours after sending the email request Comments:
public Dr.Ali,Amjadi
Seyyed Jamaledin Asad Abadi Blvd - Parks of Traffic
Sirjan Iran (Islamic Republic of) 7816916338 +98 34 4234 0640 Aamjadi50@yahoo.com Sirjan Faculty of Medical Science scientific Dr. Masoomeh Mohamadpour
No 16, Gisha Ave
tehran Iran (Islamic Republic of) 1448643643 +98 21 8827 5219 m.mohamadpour2817@yahoo.com Rayan Research Company Iran (Islamic Republic of) COVID-19 virus infection by RT-PCR in non-hospitalization and hospitalization patients G6PD sufficient in non-hospitalization and hospitalization patients Lack of clinical response to routine outpatient treatment in non-hospitalization and hospitalization patients Clinical symptoms (fever, cough, myalgia, shortness of breath, digestive problems) in non-hospitalization and hospitalization patients Age over 12 years in non-hospitalization and hospitalization patients Patient satisfaction in non-hospitalization and hospitalization patients Lymphocytes less than 15%, respiratory distress, lung involvement on CT scan, oxygen level less than 93%, unstable vital signs, severe gastrointestinal symptoms and oral intolerance, underlying disease Except for exclusion cases hospitalization patients 12 years no limit Both Allergy to oral supplements and high doses of vitamin C Reluctance to continue participating in the trial for any reason Patients admitted to the intensive care unit (ICU) (patients who have been admitted to the ICU since admission) Pregnant and lactating lady Patients with seizures Dialysis patients RA01.0 Severe Acute Respiratory Syndrome coronavirus Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: non-hospitalization patients with symptomatic COVID-19 received 1. Artemisia annua - Artemisinin ( Manufactured by Longlifenutri)150 mg every 24 hours 2. Dose of 1 g of vitamin C (Manufactured by Daroupakhsh) intravenous vitamin (2 ampoules of 500 mg in 250 cc of sodium chloride serum for 30 minutes) every 24 hours 3. Dose of 5 cc of noscapine ( Manufactured by Faran Shimi) each Eight hours 4. 500 mg dose of hesperidin (Manufactured by Swanson) every 24 hours 5. Resveratrol 500 mg (Manufactured by A Squard) every 24 hours 6. NAC 600 mg ( Manufactured by Osvah ) every 12 hours . The duration of treatment is estimated at ten days. Supplements are taken orally and vitamin C is given to patients as an injection Control group: non-hospitalization patients with symptomatic COVID-19 Protocol of the Ministry of Health Intervention group: hospitalization patients with symptomatic COVID-19 received 1. Artemisia annua - Artemisinin ( Manufactured by Longlifenutri)150 mg every 12hours 2. Dose of 1 g of vitamin C (Manufactured by Daroupakhsh) intravenous vitamin (2 ampoules of 500 mg in 250 cc of sodium chloride serum for 30 minutes) every 12 hours 3. Dose of 5 cc of noscapine ( Manufactured by Faran Shimi) each Eight hours 4. 500 mg dose of hesperidin (Manufactured by Swanson) every 24 hours 5. Resveratrol 500 mg (Manufactured by A Squard) every 24 hours 6. NAC 600 mg ( Manufactured by Osvah ) every 12 hours . The duration of treatment is estimated at ten days.Supplements are taken orally and vitamin C is given to patients as an injection Control group: hospitalization patients with symptomatic COVID-19 Protocol of the Ministry of Health LDH. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: Blood Test. CBC diff. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: Blood Test. Na/K/Ca. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: Blood Test. CRP. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: Blood Test. ESR1. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: Blood Test. Weakness and nausea. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: Check List. Lung involvement. Timepoint: Before the intervention and ten days after the intervention. Method of measurement: CT-Scan. Determination of the effect of Hesperidin,Artemisinin- Artemisia annua, Noscapine, N-acetylcysteine, Resveratrol supplements and high dose of vitamin C on on oxygen. Timepoint: 10 day. Method of measurement: Pulse Oximeter. General condition of people and vitality after treatment. Timepoint: 10 day. Method of measurement: Examination and history. Sirjan Faculty of Medical Science Approved 2020-10-07 sirjan faculty of medical science sirjan - Seyyed Jamaledin Asad Abadi Blvd - Parks of Traffic - Sirjan University of Medical Sciences sirjan Kerman Iran (Islamic Republic of)