IRCT20190208042654N4 IRCT 2021-04-12 Esfahan University of Medical Sciences The effect of acetaminophen and dexmedetomidine infusion on the severity of cataract surgery pain Comparison between the effects of Acetaminophen and Dexmedetomidine infusion and normal saline on pain severity after cataract surgery an open label randomized controlled trial 2020-11-05 anticipated 135 Complete https://irct.ir/trial/51203 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: This randomized controlled clinical trial had an equal allocation ratio for two groups of the study, Randomization description: The study population was selected on a consecutive basis. For the randomization of the participants, first, the principal investigator used the “Sealedenvelope” website to create blocks containing 9 individuals, containing three participants for each of three groups. Every participant had a unique code consisting of two letters and one number. This generated list remained confidential for participants, clinicians who enrolled the patients in the study, clinicians who injected the drugs and data analyzer. Patients have entered the study groups (A, B and C) according to the generated list, after a full explanation of the study process and obtaining written consent, Blinding description: This study is a single-blind study, where physicians and patients were aware of study groups and only the statistical analyzer was blind for treatment groups. Each group was assigned with A or B or C, which makes the analyzer blind for the treatment group. 3 Cataract. Intervention 1: Intervention group 1: infusion of Acetaminophen IV at a dose of 15 mg/kg within the first 15 minutes of surgery, slowly in total volume of 100 ml. Intervention 2: Intervention group 2: infusion of dexmedetomidine IV at a dose of 0.5 µgr/kg within the first 15 minutes of surgery, slowly in total volume of 100 ml. Intervention 3: Control group: Injection of 100 ml of normal saline in the first 15 minutes of surgery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this available