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IRCT20200914048715N1 IRCT 2020-09-20 - Comparison of the effect of ketamine and magnesium sulfate on acute asthma attack Comparison of the effect of ketamine nebulizer with magnesium sulfate in the treatment of patients with corticosteroid-resistant asthma referred to the emergency department 2020-11-05 anticipated 70 Complete https://irct.ir/trial/50948 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: People will be randomly divided into two groups. This study is such that patients who are candidates for inclusion in the study, after examination in terms of inclusion and exclusion criteria and obtaining informed consent using Block Randomization and software will be divided into two groups and patients in the first group treated with nebulizers. (0.3-0.1 mg / kg) and the second group will be treated with magnesium sulfate infusion (2 gr (within 20 minutes), Blinding description: This study was double-blind, so that the patient and the researcher were unaware of the status of the two groups assigned to the study. The researcher, who performs clinical and diagnostic measurements, was not aware of the status of individuals, and the statistical consultant was unaware of the allocation of individuals to study groups. Only one observer was aware of the allocation of groups. There will be two intervention and control groups, with standard treatment for both acute asthma attacks. 3 asthma. Intervention group: and patients will be treated with nebulizerctamine (0.3-0.1 mg / kg). Before and 30 and 60 minutes after treatment with ketamine nebulizer, PEFR was measured by peak flowmeter in the minutes before and 30 minutes and 60 minutes after treatment with vital signs, Spo2 and recorded in a questionnaire sheet and comparison of two methods by soft Analysis tools will be performed. Control group: Patients who are included in the study according to the inclusion criteria will be treated with magnesium sulfate infusion (2 gr) for 20 minutes. Before, 30 and 60 minutes after magnesium sulfate treatment, PEFR With peak flowmetry in the minutes before, 30 minutes and 60 minutes after treatment with vital signs, Spo2 will be measured and recorded in the questionnaire sheet and the comparison of the two methods will be done through analysis software.. Yes - There is a plan to make this available What will be shared: All data can be published after making it unrecognizable When: Starting from 1/4/1400 To whom: University researchers Conditions: In order to use in similar articles Where to obtain: 1.DR Mehdi Rezaei Kojani 2.Kimia Farshadfar How to obtain: Apply by e-mail first. After acceptance, access is possible by sending your official document and within about a month. Comments:
public mehdi rezari kojani
Karaj, Hesarak, Shahid Rajaei St., Shahid Rajaei Educational and Medical Center
karaj Iran (Islamic Republic of) 3197635141 +98 26 3457 0030 rezaei.mehdi.md@gmail.com Karaj University of Medical Sciences scientific mehdi rezaei kojani
Karaj, Hesarak, Shahid Rajaei St., Shahid Rajaei Educational and Medical Center
karaj Iran (Islamic Republic of) 3197635141 +98 26 3457 0030 rezaei.mehdi.md@gmail.com Karaj University of Medical Sciences Iran (Islamic Republic of) age<65 age<>18 Corticosteroid-resistant asthma attack No history of allergy to ketamine or sulfamide 18 years 65 years Both Dissatisfaction with participating in the study age<18 age>65 weight>40 Drug or alcohol poisoning Active psychiatric illness History of ketamine allergy Treatment - Drugs Intervention group: and patients will be treated with nebulizerctamine (0.3-0.1 mg / kg). Before and 30 and 60 minutes after treatment with ketamine nebulizer, PEFR was measured by peak flowmeter in the minutes before and 30 minutes and 60 minutes after treatment with vital signs, Spo2 and recorded in a questionnaire sheet and comparison of two methods by soft Analysis tools will be performed. Control group: Patients who are included in the study according to the inclusion criteria will be treated with magnesium sulfate infusion (2 gr) for 20 minutes. Before, 30 and 60 minutes after magnesium sulfate treatment, PEFR With peak flowmetry in the minutes before, 30 minutes and 60 minutes after treatment with vital signs, Spo2 will be measured and recorded in the questionnaire sheet and the comparison of the two methods will be done through analysis software. Type of treatment - Hospitalization requirement - Acute refractory asthma attack - PEFR. Timepoint: 0-30-60 MIN. Method of measurement: Ketamine protocol - number of patients admitted - peak flowmetry. -. Timepoint: -. Method of measurement: -. - Approved 2020-05-30 ethics commitee of Alborz University of Medical Sciences Karaj - 45 meters from Golshahr - Saffarian Alley - Deputy of Research and Technology karaj Alborz Iran (Islamic Republic of)