IRCT20200910048678N1 IRCT 2020-12-01 Zanjan University of Medical Sciences Comparison of the effect of Lidocaine and Granisetron on postoperative nausea and vomiting Comparison of the effect of Lidocaine and Granisetron on postoperative nausea and vomiting in laparoscopic cholecystectomy 2020-09-19 anticipated 120 Complete https://irct.ir/trial/50897 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random allocation of samples to study groups is done by block randomization method within a block size of 4. To be more accurate, block randomization is performed by using R statistical software and is provided for the researcher who is responsible for collecting samples, and participants are divided into three groups based on the code assigned to each treatment (A, B, C) without researcher's interference, Blinding description: The patients know they are participating in a study that is aimed to evaluate the effect of Lidocaine and Granistrone on the treatment of postoperative nausea and vomiting but they are not informed that they receive Lidocaine or Granistrone or not receive any medication. Drugs are coded and the anesthesiologist who injects the drug are not aware of the medication that patients receive. 3 Cholecystitis. Intervention 1: Patients in intervention group 1, at the end of the surgery (after discontinuation of anesthetic drugs) and before extubation, receiving 1.5 mg/kg of lidocain 2% (manufactured by Caspian Tamin Company) intravenously. Intervention 2: Patients in intervention group 2, at the end of the surgery (after discontinuation of anesthetic drugs) and before extubation, receiving 3 mg of Granisetron (manufactured by Caspian Tamin Company) intravenously. Intervention 3: Control group: They do not receive any intervention. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.